Archive

The Impact of Age and Patient-Related Factors on the Administration of Chemotherapy for Older Patients with Breast and Colorectal Cancer: A Prospective Cohort Study

Doris Van Abbema; Marjan Van Den Akker; Franchette Van Den Berkmortel; Maud Koopmans; Laura Deckx; Frank Buntinx; Ingeborg Vriens; Judith Vos-Geelen; Vivianne Tjan-Heijnen*

   This study aims to investigate the relationship between age and chemotherapy use in patients with Breast Cancer (BC) and Colorectal Cancer (CRC) while considering other patient-related factors. By investigating patient-related factors and their independent predictive impact on chemotherapy utilization, this research endeavors to enhance the understanding of treatment decision-making and improve patient outcomes in this vulnerable population.


Local Recurrence of Breast Cancer after Mastectomy Impact of Residual Tissue on Oncological Follow-Up

Marta Jiménez- Gómez*; Carlota Duch; Pau Nicolau-Batalla; Mar Vernet-Tomás; Rodrigo Alcantara Souza; Nuria Argudo-Aguirre

   Conservative surgery is the standard treatment for breast cancer. However, there are cases in which mastectomy is imperative. There is a risk of developing local recurrence of 2-9.5% according to the literature.


Radiation-Induced Organizing Pneumonia after Hypofractionated Whole Breast Radiotherapy for Breast Cancer

Eleni Kohilakis*; Michael Pennock; Justin Tang; Jana Fox

   Radiation-Induced Organizing Pneumonia (RIOP) is a rare complication observed after breast irradiation with few reported cases in the literature. We present the case of a premenopausal 40-year-old female who presented with ER+/PR+/HER2- invasive ductal carcinoma in the right axillary tail.


Understanding Apocrine Metaplasia of the Breast: A Closer Look at a Complex Phenomenon

Abdel Selim*; Ghada Elayat

    This editorial provides a comprehensive exploration of apocrine metaplasia in the breast, delving into its clinical implications, diagnostic challenges, and potential causes. While generally benign, apocrine metaplasia poses difficulties in accurate diagnosis due to its resemblance to more serious conditions.


Transcription Factor SOX3 Regulates Epithelial‑mesenchymal Transition in Human Breast Cancer Cell Line MDA‑MB‑231

Felipe Henrique De Souza Silva*; Adam Underwood; Camila Pereira Almeida; Bruna Mendes Lima; Emerson Soares Veloso; Barbara Andrade de Carvalho; Thais Salviana Ribeiro; Geovanni Dantas Cassali; Enio Ferreira; Helen Lima Del Puerto

    Transcription factors proteins play essential roles in regulating cellular events in breast cancer that mediate or contribute to tumorigenesis. Embryonic transcription factors, such as SOX proteins, are key players regulating the balance between Epithelial-Mesenchymal Transition (EMT) and the reverse Mesenchymal-Epithelial Transition (MET).


Management of Neck Metastasis in Operated Case of Breast Carcinoma by Laser Ablation in a her2 Positive Case - A Case Report

Rusy Bhalla; Seemantini Bhalla M.S; Duleep Bhonsale M.D

    It is well known fact that shower metastasis is quite common occurrence after Breast cancer surgery. The appearance of distant metastasis after surgery is commonly treated by Chemotherapy and lately addition of Immunotherapy has increased the overall survival.


Mammography in Nigeria: A Rigorous Retrospective Analysis of One-Year Utilization in a Tertiary Hospital

Adeleye Dorcas Omisore

    Background: Mammography screening is the most effective way to minimize breast cancer morbidity and mortality. Unfor tunately, the uptake of mammography in Nigeria has been low.


Serum Vitamin D Deficiency and Risk of Breast Cancer: A Case-Control Study among Multiethnic Women in Malaysia

Tania Islam; Anis HAJ; Nirmala Bhoo-Pathy; Muhammad Yazid Jalaludin; Foong Ming Moy; Nur Aishah Taib*

    Despite emerging studies suggest the beneficial role of vitamin D, evidence on the relationship between vitamin D deficiency and risk of getting breast cancer is till now inconsistent and scarce in Southeast Asia. Therefore, we intended to explore the association between serum 25(OH)D and the risk of breast cancer among the Malaysian woman.


“Analysis of the Relationship of the Grades of Invasive Ductal Carcinoma with the Ki-67 Index in Breast Cancer Patients and Its Application in Third World Countries”

Jyoti Taneja*; Viraj Borgaonkar; Vijay Borgonkar; Vikas Agrawal; Prassana Somvanshi

    We aim to analyse the relationship of the grades of Invasive Ductal Carcinoma with the KI-67 index in breast cancer patients and, stratifying patient prognosis and to create a comprehensive prognostic index for clinical applications. A mono-institutional cohort for cancer breast patients having complete clinical, radiological, histological, and follow-up data. The <20% and >20 % Ki67 cut-offs were correlated to IDC grades, lymph-node positivity and tumor size...


Ultrasonography Changes After Laser Ablation of Breast Carcinoma

Rusy Bhalla*; Seemantini Bhalla; Duleep Bhonsale; Ashish Kapadia

    Introduction: Minimal invasive treatment for breast cancer has been introduced under various technologies. Chief amongst them are ablation techniques like Laser, Radiofrequency, Micro-ablation and Cryo-ablation.
The advantages of Laser Ablation are reduced procedure time and real time visualization of tumour.
Material and procedure: 12 patients were subject to laser ablation of tumour between 2008 and 2021. All patients were unwilling to undergo formal mastectomy and were in Stage 3 by Manchester classification.


A Diagnostic Conundrum of Solitary Thyroid Nodule in Breast Cancer-Second Primary or Metastasis? A Case Report with Review of Literature

Nisha Prasannan; Paul Augustine*; Rexeena V Bhargavan

    The rising incidences of breast and thyroid cancer in women has resulted in them becoming among the commonest malignancies in females [1]. The common sites of metastasis from breast cancer are lymph nodes, bones, lungs and liver. Metastases to the thyroid gland from a non-thyroid primary are uncommon and are mostly from the kidney, followed by gastrointestinal tract, lungs, skin, and rarely breast [2]. Synchronous primary tumors of the thyroid and breast are also very rare in clinical practice.


Preliminary Local Experience with Breast Magnetic Resonance Imaging on Surgical Planning and Outcomes

Sherwin Kuah; Niketa Chotai; Juliana JC Chen; Mui Heng Goh; Patrick MY Chan; Ern Yu Tan*

    Background: Breast Magnetic Resonance Imaging (MRI) has been shown superior to mammography and ultrasound in terms of cancer detection and tumour size estimation. However, breast MRI is seldom done at our unit because of its cost.
Aims: We reviewed 31 women (32 cancers) who had pre-operative MRI and evaluated the impact of additional MRI-detected lesions on surgical planning and margin status.


Manual vs Digital Scoring of Ki67 in Breast Cancer using an Automated Image Analysis System: An Interobserver Variability Study

Ahsan Siddiqi, MD; Helena Hanna; Xochiquetzal J Geiger, MD; Aziza Nassar, MD, MPH, MBA*

    Objectives: We sought to validate the use of Digital Image Analysis (DIA) with the Aperio Digital Scanner (Leica Biosystems) for assessment of Ki67 proliferation Labeling Index (LI) in patients with Breast Cancer (BC) and compare the results with the manual method of Visual Assessment (VA).
Methods: We retrospectively identified 87 patients with BC and retrieved paraffin-embedded, whole-tissue sections for Ki67 immunostaining (monoclonal MIB-1 clone)...


Risk Assessment-Based Breast Cancer Screening Programs: A U.S. Environmental Scan

Susan R Snyder*; Dina Hassen; Alanna Kulchak Rahm; Jing Hao; Samantha Crissinger; Qiang Hao; Mallory Snyder; Rosemary Leeming;

    Objective: A paradigm shift has occurred in evidencebased breast cancer screening and prevention recommendations towards a personalized risk assessment-based approach. A resulting trend is dramatic growth in new High Risk Breast Clinic (HRBC) programs incorporating a frontend risk assessment. There is a lack of standardized information on the implementation of these emerging programs which are characterized by substantial variation.


Targeting Deep Breast Lesion in a Cost Effective Way

Teena Sleeba*; Michelle Aline Antony

    Introduction: A 56 year post-menopausal lady presented with a left breast mass lesion of 3 month duration. Mammograms in CC and MLO views revealed multifocal left breast malignancy involving the upper outer quadrant of the left breast with metastatic left axillary nodes. A subtle 4 x 4 mm nodular lesion with three specks of pleomorphic microcalcifications concerning for DCIS were also seen in the right breast.


Protocol of the TOBO-Study: A prospective cohort study of patient satisfaction and quality of life after breast conserving therapy with and without oncoplastic reconstruction

Nadine S Hillberg*; Yvonne LJ Vissers; Karolien MPJ Verhoeven; Tom JM van Mulken; Marleen AJ Meesters-Caberg; Liesbeth J Boersma; René RJW van der Hulst

    Introduction: In the past, a mastectomy was the first approach to the treatment of breast cancer. Today, breast-conserving surgery combined with adjuvant radiotherapy has become the standard treatment for a large number of women with breast cancer. Even for resection of larger tumours, which previously could only be treated with a mastectomy, breast-conserving surgery in combination with oncoplastic reconstruction is possible with a good cosmetic result...


Predictors of complete response to neoadjuvant chemotherapy in Breast Cancer: A National Cancer Database (NCDB) analysis

Marissa K Srour; Jeffrey Johnson; Alice Chung; Armando E Giuliano; Farin Amersi*

    Purpose: Pathologic Complete Response (PCR) following Neoadjuvant chemotherapy (NAC) for breast cancer has been associated with improved survival. The objective was to characterize those patients receiving NAC and analyze predictors of PCR.


Comparison between HER2 extracellular domain in serum and HER2 overexpression in breast cancer tissue in the same patients

Jamal Zidan; Raneen Mzalbat; Adi Sharabi; Moshe Stein; Osamah Hussein

    Background: Human epidermal growth factor receptor 2 (HER-2) is an important prognostic and predictive factor in women with breast cancer (BC). The importance HER-2 extracellular domain (ECD) in serum is not yet determined. The aim of this study was to explore the correlation between serum ECD and tissue HER-2 expression and to compare ECD levels with clinical and pathological features in primary BC patients.


Primary male breast leiomyosarcoma: An unusual case successfully treated by surgery and radiotherapy

Mohammed Afif*; Fadila Kouhen; Hanan Elkacemi; Noureddine Benjaafar

    Background: Primary sarcoma of the breast represent less than 1% of all breast malignities, and leiomyosarcoma are extremely rare. We report an unusual case of leiomyosarcoma of the breast in a Moroccan man.


Green Synthesized Gold Nanoparticles using Plant Extracts as Promising Prospect for Cancer Therapy: A Recent Review

Temesgen Orebo Abire

    Green synthesis methods are gaining significance as promising routes for the sustainable preparation of nanoparticles, offering reduced toxicity towards living organisms and therefore the environment. Among nanoparticles, gold nanoparticles (AuNPs) attract much attention thanks to their usability and high performance in imaging techniques. The wide availability of biological precursors employed in plant based synthesized AuNPs allows for the event of large-scale production during a greener manner...


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