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The Impact of Age and Patient-Related Factors on the Administration of Chemotherapy for Older Patients with Breast and Colorectal Cancer: A Prospective Cohort Study

Doris Van Abbema; Marjan Van Den Akker; Franchette Van Den Berkmortel; Maud Koopmans; Laura Deckx; Frank Buntinx; Ingeborg Vriens; Judith Vos-Geelen; Vivianne Tjan-Heijnen*

   This study aims to investigate the relationship between age and chemotherapy use in patients with Breast Cancer (BC) and Colorectal Cancer (CRC) while considering other patient-related factors. By investigating patient-related factors and their independent predictive impact on chemotherapy utilization, this research endeavors to enhance the understanding of treatment decision-making and improve patient outcomes in this vulnerable population.


Local Recurrence of Breast Cancer after Mastectomy Impact of Residual Tissue on Oncological Follow-Up

Marta Jiménez- Gómez*; Carlota Duch; Pau Nicolau-Batalla; Mar Vernet-Tomás; Rodrigo Alcantara Souza; Nuria Argudo-Aguirre

   Conservative surgery is the standard treatment for breast cancer. However, there are cases in which mastectomy is imperative. There is a risk of developing local recurrence of 2-9.5% according to the literature.


Radiation-Induced Organizing Pneumonia after Hypofractionated Whole Breast Radiotherapy for Breast Cancer

Eleni Kohilakis*; Michael Pennock; Justin Tang; Jana Fox

   Radiation-Induced Organizing Pneumonia (RIOP) is a rare complication observed after breast irradiation with few reported cases in the literature. We present the case of a premenopausal 40-year-old female who presented with ER+/PR+/HER2- invasive ductal carcinoma in the right axillary tail.


Understanding Apocrine Metaplasia of the Breast: A Closer Look at a Complex Phenomenon

Abdel Selim*; Ghada Elayat

    This editorial provides a comprehensive exploration of apocrine metaplasia in the breast, delving into its clinical implications, diagnostic challenges, and potential causes. While generally benign, apocrine metaplasia poses difficulties in accurate diagnosis due to its resemblance to more serious conditions.


Transcription Factor SOX3 Regulates Epithelial‑mesenchymal Transition in Human Breast Cancer Cell Line MDA‑MB‑231

Felipe Henrique De Souza Silva*; Adam Underwood; Camila Pereira Almeida; Bruna Mendes Lima; Emerson Soares Veloso; Barbara Andrade de Carvalho; Thais Salviana Ribeiro; Geovanni Dantas Cassali; Enio Ferreira; Helen Lima Del Puerto

    Transcription factors proteins play essential roles in regulating cellular events in breast cancer that mediate or contribute to tumorigenesis. Embryonic transcription factors, such as SOX proteins, are key players regulating the balance between Epithelial-Mesenchymal Transition (EMT) and the reverse Mesenchymal-Epithelial Transition (MET).


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