IMPACT FACTOR: 1.8
Short Name: J Nanomed
ISSN: 2578-8760
Publisher: MedDocs Publishers LLC
The COVID-19 emergency has created a widespread need for proper care, prognosis, and prevention of viral dissemination. Nanotechnology has been at the centre of attention for the rapid development of diagnostic instruments, anti-viral therapy and vaccinations worldwide. This review highlights the current and continuing nanotechnology-based therapeutic and preventive techniques for combating COVID-19
To create and evaluate an in situ medication delivery system for the eyes to improve its residence duration and hence its bioavailability in the ocular mucosa. Methods: Carbopol is a pH-dependent water soluble in situ polymer. When the pH was alkaline, the carbopol polymer formulations stayed as a solution at acidic pH and formed a low-viscosity gel.
Synthetic packaging materials are neither reprocessable, renewable nor biodegradable barrier and also difficult to recycle into useful products. While cellulose-based packaging is widely known as a renewable, reprocessable, recyclable and biodegradable material it has limited air and water vapour barrier properties.
The present research work aims to prepare a unique formulation (Gel) containing a lipidic vesicle of extract having the dual therapeutic purpose of achieving great skin simultaneously with improved haemoglobin content. Ethosomes were prepared using soya phosphatidylcholine (1-4%) and ethanol (10-40%).
Aluminum (Al) is an environmental neurotoxin to which humans are widely exposed and which is associated with motor and cognitive impairment and is most commonly associated with neurodegenerative diseases; it can cause abnormal phosphorylation of the tau protein and cognitive impairment.
The pericardium provides a unique site and an enclosed volume for the delivery of drugs to the heart and coronary arteries. In this review emphasis is given on strategies for more localized release and sustained delivery approaches (myocardial patches, cardiac meshes, hydrogels and nanoparticles) to the heart.
Functionalized Nanoparticles (FNPs) using small or macromolecules have attracted research interest in targeted drug/gene delivery, tissue engineering, and imaging applications. The raffinose trisaccharide is the smallest raffinose oligosaccharides that has been used in fish's dietary supplements. Trisaccharides usually attached at the edge of Graphene Oxide (RafGO) nanosheets.
Metal nanoparticles (NPs) have the highest effectiveness among the most innovative nanotechnological applications due to their special action modes. For instance, Ag+ ions are broad-spectrum antibacterial agents with the capacity of effective inhibition of the growth of fungi, algae, and bacteria. Nanoscale silver particles with a large surface-area-to-volume ratio (size below 100 nm) are significantly interesting because of their great antimicrobial actions against viruses, Gram-negative and Gram-positive bacteria.
In this article the interaction of human serum albumin (HAS) with a copper complex [Cu(HEAC)Br]Br containing of bromide and 2-(2-(2-Hydroxyethylamino)ethylamino)cyclohexanol (HEAC) ligands was investigated. To have a better understanding over the interaction mode multispectroscopic methods such as UV–vis, fluorescence, CD spectroscopy along with molecular docking studies were used.
Silver nanoparticles are increasingly being employed as antimicrobial agents especially as a new approach for combating infectious diseases caused by multidrug resistant microorganisms. In this study, we will determine in vitro hemolytic potential of Carboxy Methyl Cellulose (CMC) stabilized serum capped silver nano particles (AgNPs) in human blood characterizing physical, antimicrobial and hemolytic properties of AgNPs that contribute to Red Blood Cell (RBC) morphology defining proper safety margins.
Use of copper to cater various needs of human civilization started immediately after the neolithic age. However, the nano-formulation of copper containing copper or one of its compounds including oxides in order to combat some of the societal challenges are quite recent. Here we have synthesized copper oxide nano particles and functionalized with acetate ligands to form a nano-hybrid which is shown to have medicinal properties.
Neurological diseases incidence led to the poor quality of life in several patients subsequently results in the higher mortality rate. The rapid advancement in the nanotechnology is leading to the design of nanotherapeutics in the form of nanocarrier systems to target the pathophysiology of epilepsy, and neurodegenerative diseases such as Alzheimer’s Disease (AD), and Parkinson’s Disease (PD).
HPV infection is one of the leading causes of cancer mortality in women worldwide. Early treatment of the precancerous lesions would prevent the progression of cervical cancer. The oncogenic viral proteins namely E2, E6, and E7 play a critical role in the regulation of the cell cycle, immortalization, transformation of cervical cells, and maintaining the chromosomal integrity.
Nanotechnology and Nanoscience is a multidisciplinary field to exploit the wide spectrum of the emerging area from fundamental sciences with novel techniques. Nanoparticles have greater surface area to volume ratios. Up to now, numerous biological organisms are described to have their potentiality for the synthesis of metallic nanoparticles. Green synthesis is a gradually evolving research area that used to extract nanoparticles from plants...
Rheumatoid arthritis is a chronic autoimmune illness, predominantly affecting elder women over men. Janus Kinase 2 (JAK2) is a non-receptor tyrosine kinase, belonging to the Janus kinase (JAK) family involved in the activation of the JAK/STAT signaling pathway and it plays an important role in several biological processes, such as cell proliferation, differentiation, apoptosis, and physiological and pathological activity...
Fabricated Hydroxyapatite (HA) nano-particles that mimic natural HA are extensively used as coatings on prostheses to repair, renovate and replace human bones. However, the attainability of these materials is limited for developing countries due to the high cost of both raw materials and material processing. Therefore, Wijesinghe et al...
Recent developments in our understanding of communicable diseases have been marked by remarkable progress. The COVID 19 pandemic has increased the importance of research and study of biological hazards. According to the FAO reports, 75% of emerging diseases are zoonoses. The main reasons for the spread of infectious diseases are globalization, climate change and the intensification of agriculture...
DNA encodes genetic instructions relevant to the development and functioning of living organisms and viruses. One of the primary regulators of gene transcription is DNA methylation. DNA methylation occurs at specific sites in DNA, referred to as genetic hot spots or CpG islands. However, aberrant DNA methylation patterns such as hypermethylation and hypomethylation have been recognized in variety of human malignancies...
The aim of present research is to evaluate the decontamination of nerve agent sarin simulant Dimethyl Methyl Phosphonate (DMMP) in water media using the CuO/ZnFe2O4/NaA zeolite as a novel ternary nanocomposite adsorbent. In this regard, the CuO and ZnFe2O4 nanoparticles were successfully synthesized within the NaA zeolite applying the ultrasound-assisted hydrothermal route and characterized via XRD, FESEM, FTIR, EDAX, VSM and BET analyses...
Piroxicam is an oxicam-class nonsteroidal anti-inflammatory medication used to treat gout, arthritis, and other inflammatory diseases (orally, topically). Because piroxicam is practically insoluble in water, the purpose of this research is to manufacture and test it as a liquid self-nano emulsifying system for delivering drugs in order to enhance its stability as well as dispersibility. For determining the optimum materials to dissolve piroxicam, dispersibility and stability study was undertaken in Oil, Surfactants, and Co-surfactants...
Piroxicam is an oxicam-class nonsteroidal anti-inflammatory medication used to treat gout, arthritis, and other inflammatory diseases (orally, topically). Because piroxicam is practically insoluble in water, the purpose of this research is to manufacture and test it as a liquid self-nano emulsifying system for delivering drugs in order to enhance its stability as well as dispersibility. For determining the optimum materials to dissolve piroxicam, dispersibility and stability study was undertaken in Oil, Surfactants, and Co-surfactants...
This article discusses the composition, structure, mechanical properties, and biological applications of alumina (Al2O3). Implants are made of single crystal sapphire or high-density, high-quality polycrystalline aluminium oxide. The principal sources of high-purity aluminium oxide are organic corundum and bauxite. Like any other component, the mechanical characteristics of polycrystalline alumina are mostly governed by grain size and porosity distribution...
Background: Cardio-vascular illness is the most common disease in the world. Coronary Artery Diseases (CAD) are cardiovascular inflammatory diseases. CAD is a multifactorial disease. Recently, some infectious agents such as Helicobacter pylori (H. pylori) have been suggested that have a key role in the pathogenesis of CAD. The current study aimed to investigate the presence of H. pylori acid nucleic atherosclerotic plaques in coronary blood vessel by the PCR and the relationship between the existence of H. pylori DNA and CAD.
Objective: Metal or metal oxide nanoparticles have attracted the recent researchers much for their suitable applications and easy way of synthesis. This synthesis is based on biological reduction that uses plant extract as it is simple and it can integrate the chemical technology. An attempt has been made to understand the synthesis of Ag-Cu ANPs material by biological reduction of silver salt and copper salt using Butea monosperma leaf extract.
Nickel is a hazardous metal that cause cancer and many other diseases. Agar coated magnetic iron oxide nanoparticles was investigated for the elimination of nickel from waste water. The magnetic nanoparticles were formed using a co-precipitation method from natural iron source. The nanoparticles have been described by a study of FT-IR, SEM, XRD and EDX...
Magnetic Nanolipase (MNL) was prepared previously in our lab and the potential applications were explored in the present work. Two types of reactions including hydrolysis of olive oil and synthesis of vitamin A palmitate were chosen to check the properties of MNL. When concentration of olive oil was 25% (v/v) immobilized lipase has the highest activity (80.7 U/g) under 50°C...
This study was conducted to determine the main compounds of Henna are: Quinine, lawson naphoquinone, resin, gallic acids, glucose, manitol, and the tannins, which the main material in our work. The tanning materials were extracted with water as a solvent at a temperature of 40Co. The average tannins content were determined and were found to be 11.2% on weight basis. The type of tannins was identified to be condensed type of tannins...
Background: Silver nanoparticles are the leading in biomedical applications such as antioxidant, anticancer, antiviral, antidiabetic and antimicrobial because of their biocompatibility and stability. The activities of AgNPs synthesized using plant extracts is significantly improved due to phytochemical coating. The aim of this review is to explore the anticancer activity of AgNPs synthesized via plant extracts...
In this study, the effects of increasing sonication times (0 min, 60 min, 120 and 150 min), sonication temperatures (25°C, 30°C and 60°C), on the dissolved chemical oxygen demand (CODdis), Total Organic Carbon (TOC) and total Polycyclic Aromatic Hydrocarbons (PAH) removal efficiencies were monitored at a sonication frequency of 35 kHz and a sonication power of 640 W for a raw Petrochemical İndustry Wastewater (PCI ww)...
Bioactive nano-hydroxyapatites have been synthesised for orbital floor repair and regeneration. Hydroxyapatite (HA) is widely used for bone repair and regeneration. It is composed of multiple anionic and cationic species, such as carbonate, fluoride, phosphate, sodium, magnesium, silicon and citrate. However, the development of bioactive materials that can repair and regenerate bone is crucial for orbital floor fracture repair...
Biopolymer–lipid nanocarriers as hybrids are upcoming and have been most assuring frontiers in both pharmaceutical and biomedical research areas. In last decade, great focus is oriented in the development of functionalized nanocarriers by amalgamation of biopolymer and lipids with inherit specific properties of organic, inorganic nanocarriers and the lipid structured particles (liposome, lipoprotein, solid lipid nanoparticle, and nanoemulsion, nanocrystals) for specialized properties and functions.
Objectives: To evaluate the therapeutic potential of phytofabricated silver nanoparticle reduced by bark extract of Saraca asoca for Acute Myeloid Leukemia (AML).
Methods: The efficacy of silver nanoformulation was tested in vivo secondary model of AML in comparison to chemotherapeutic drug doxorubicin and the cytotoxic and genotoxic potential of the nanoparticle in vitro in leukemic cells in comparison to normal lymphocytes.
Objective: The aim of the current study was to formulate and evaluate desonide loaded microemulsion gel for effective management of Atopic Dermatitis (AD).
Methods: Microemulsions (MEs) were developed and optimized using D-optimal mixture statistical experimental design. The morphology of ME was studied using transmission electron microscopy. To improve skin retention of formulation, gelling of the optimized ME was carried out using Carbopol 940 (1% w/w). The efficacy of the formulation was evaluated on mice with..
Cold induced aggregation micro extraction technique combination with spectrophotometry was used to preconcentrate and detect aluminum in biological and environmental samples. The pocedure is depending on Al (III) complexation with 2-amino-4-(m-tolyazo) pyridine-3-ol (ATAP), and entrapped in non-ionic surfactant octylphenoxy polyethoxy ethanol (Triton X-114). In the present method, sodium hexafluorophosphate (NaPF6) was broughted to the sample solution having smalest levels of 1-hexyl-3-methylimidazolium hexafluoro-phosphate [Hmim] [PF6] as extraction solvent...
Lipid Nanoparticles (LNPs), which consist mainly of cationic lipids, are considered a promising gene delivery tool for gene therapy with advantages such as ease of manufacturing and reduced toxicity. Human Peripheral Blood Mononuclear Cells (hPBMCs) are an important raw material for gene therapy and there is a need to develop tools for effectively delivering genes to them. LNPs are expected to be a suitable delivery tool for this purpose.
Dry Age-related Macular Degeneration (AMD), which has no cure, is the leading cause of vision loss in the elderly in many parts of the world. The pathogenesis of AMD involves the slow degenerative loss of the Retinal Pigment Epithelium (RPE), likely due to oxidative stress. In addition, recent evidence has emerged suggesting that blue light emitted from smartphones, laptops and other devices can penetrate the lens of the eye and cause similar oxidative damage to the RPE, with the same ultimate fate of progressive blindness.
Purpose: The aim of the present work was carried out by the principles of quality by design approach to optimize thermo-responsive in-situ hydrogels. To recognize the effect of formulation variables (parameters) on the response of in-situ gels, a 3 factor, 3 level Box- Behnken design, was explored to expect the responses such as Viscosity (Y1), Temperature of gelling time (Y2) and % Cumulative drug release (Y3) when the concentration of poloxamer (X1), HPMC K200M (X2) and HPMC low viscous (X3) were selected as independent variables.
The human effort for maintaining a healthy body that could function effectively in complete harmony with human’s environment, has brought a lighting up to the innovative therapeutic approaches [1]. Meanwhile, the battle with various genetic diseases has witnessed tremendous advances, therefore, scientists learned to profit from neoteric features of nanotechnologies for controlled and targeted tracking of the proteins and gene to cells.
In the last few years, the application of nanotechnology in agriculture has created new opportunities for developing nanosized agrochemicals that have the potential to improve efficiency, enhance stability, prolong the effective duration and at the same time reduce environmental loads. One of the critical challenges in the agricultural industry is the need to address issues associated with the pesticide’s use as environmental contamination, bioaccumulation, and increases in pest resistance, which demands a reduction in the quantity of pesticide applied for crop and stored product protection.
Coronaviruses (CoVs) such as α-CoVs, β-CoVs, and COVID-19 are a wide group of viruses that include viruses that can cause a group of disorders in humans, ranging from a common cold to severe acute respiratory syndrome. Given the diffculties the world is experiencing in the face of the Coronavirus, which has spread from China, everyone is trying to find an antibiotic and reduce its spread, but to the extent that there is no effective vaccine.
As the deadly virus is continuing to infect the entire population of the globe, proper protection against the novel coronavirus has become extremely crucial. The virus is entering through our nostrils casusing extensive damage to the tissues of the lungs and wearing a good mask has become mandatory to the virus attack.
Keto-acid derivatives of sulfated iota -carrageenan (ICAR) was quantitatively prepared by the oxidation of iota- carrageenan as sulfated macromolecules by potassium permanganate in alkaline medium at pH`s > 12. The diketo-derivative was characterized by formation of 2,4-dinitrophenyl hydrazone and dioxime derivatives when reacting with 2,4-dinitrophenyl haydrazine and hydroxyl amine, respectively.
The work quantitatively studied the leaching into water of Ag and Cu ions, from Ag and Ag/Cu nanoparticles (NPs) fixed on the surface of bactericidal tissues –cotton fabrics (cf) in the form of complexes with tryptophan (Trp) molecules. The effect of the modification of Ag/Cu NPs in cotton tissues by Trp on their bactericidal activity is studied.
During manufacturing of ultra-high diluted succussed solution medicinal products from solid origin source materials, the preparation process is close linked to the trituration in α-lactose monohydrate. The α-lactose monohydrate in these cases is used as friction substance and this process leads the solid source materials to become micro-nano particles as we have clearly shown in a previous study.
Ultra high diluted medicinal products are made by serial dilutions which are always followed by “succussion”. The aim of this work is to investigate the impact of the succussion on the nature of these solutions, when a source material is triturated up to micro and nanoscale particles and then used to prepare ultra-high diluted medicinal products.
Cancer is a major public health concern and the second most common cause of deaths globally behind cardiovascular diseases. According to estimates from the World Health Organization, in 2018, cancer accounted for 9.6 million deaths or one in six deaths worldwide. As per American Cancer Society estimates, in 2020, 1,806,590 people are expected to get cancer and 606,520 will succumb to this disease in the United States.
Arnica Montana is a very useful and widely used medicinal plant by established, traditional, complementary and Alternative Medicine. This manuscript describes the physicochemical evaluation of ultra high diluted-succussed solution products based on Arnica Montana (starting material) as they are used like remedies by TM/CAM (Homeopathy).
In this article, we introduce an efficient and reusable catalyst for the synthesis of biologically active xanthene derivatives through a one-pot condensation of aldehydes, 2-naphthol, and dimedone, using the novel dicationic Brönsted acidic ionic liquid
This paper introduces a new international standard [(International Organization for Standardization/Technical Specification (ISO/TS) 20660)]: Specification of characteristics and measurement methods for silver nanoparticles. The new standard provides a guideline of essential and additional characteristics for silver nanoparticles used as antibacterial agents in consumer products, along with the relevant measurement methods.
The present study aims nanoscopic observation and detection of rhodopsin (a G protein- coupled receptor) nanodomains in their native biological environment to investigate their kinematics related to the photocycle. In the first phase of the planned work, the retina segments were obtained from bovine eyeballs and different sample preparation methods were tested to identify the densely packed rhodopsin nanodomains.
In this article, we examined the surface topography and frictional characteristics (cartilage/cartilage) pair normal and osteoarthritic bovine cartilage. The amount of structured synovial fluid hydrated (lubricin-hyaluronan) complex is not enough to resist the effects of loading and friction...
Objective: Gold nanoparticles (GNPs) have the potential to enhance the effects of radiation therapy, using Auger electrons to cause additional damage to tumors. In this work, we explore the effect of two clinically important variables: dose fractionation and radiation energy. In clinical radiation therapy, radiation is fractionated (split into multiple sessions) and high-energy radiation is used. However, in the field of GNP research, radiation has generally been given in one session and lower radiation energies have generally been used.
Poor solubility, high toxicity, nonspecific delivery and short circulating half-lives are the disadvantages of conventional drug delivery of the anticancer agents.
In the field of nanoparticle based drug delivery, controlled delivery of therapeutic compounds has been a matter of great interest. Unconcealed toxicity, poor selectivity, narrow therapeutic index, and high probability of developing drug resistance are the disadvantages of nanoparticle based chemotherapeutics.
This paper reviews the research progress of Mesoporous Silica Nanoparticles (MSNs) in the construction of drug carrying system in past studies. Through the design of its structure and chemical properties, drug carrying system with various functions can be prepared, which is suitable for drug sustained release system and targeted treatment of various pathological tissues, thus representing a revolutionary biological nano technology.
Radiation therapy is one of the most commonly used techniques for the treatment for cancer. A major goal of radiation therapy is to damage cancer cells, while simultaneously imparting as small a radiation dose as possible to nearby healthy cells. Due to a high atomic number and the Auger effect, gold nanoparticles can significantly enhance doses of ionizing radiation. The amount of enhancement due to gold nanoparticles strongly depends upon several parameters, such as cellular uptake of nanoparticles, nanoparticles size, concentration, intracellular location and radiation energy.
Overwhelming results of CAR-T cells cancer immunotherapy for the treatment of lymphoma have offered an excellent opportunity to explore the efficacy of CAR-T cell therapy in other malignancies. However, less exciting results derived from CAR-T cells treated solid tumors demand an urgent need to investigate the possible hurdles in the path of this therapy. CAR-T cell infiltration barriers and immunosuppressive tumor microenvironment efficiently influence the therapeutic outcomes.
Objectives: A decrease in bacterial counts as a consequence of their interactions with various carbon nanotubes are usually interpreted as the destruction of viable bacteria. However, changes in adherent properties can also result in a decrease of the detectable bacterial counts. Methods: This paper provides a simple experimental setup and a mathematical formulation for simultaneous determination of ratios of the live/dead and adherent/non-adherent bacteria based on impedance changes.
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Authors
Irene Bonadies
Institute of Polymers, Composites and Biomaterials (IPCB) – CNR, Pozzuoli, Italy
Received: Dec 20, 2017
Accepted: Jan 12, 2018
Published Online: Jan 18, 2018
Authors
Ignazio Blanco
Department of Civil Engineering and Architecture, University of Catania, Catania, Italy
Received: Nov 13, 2017
Accepted: Jan 15, 2018
Published Online: Jan 18, 2018
Authors
Xuanrong Sun*; Dabu Zhu; Yue Cai
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China
Received: Dec 27, 2017
Accepted: Jan 22, 2018
Published Online: Jan 24, 2018
Authors
Ilkeun Lee
Department of Chemistry, University of California, Riverside, USA
Received: Jan 04, 2018
Accepted: Jan 26, 2018
Published Online: Feb 14, 2018
Authors
Liqun Yang1 *; Zhipeng Hou2
1 Key Laboratory of Reproductive Health and Medical Genetics, National Health and Family Planning Commission, China
2 Center for Molecular Science and Engineering, College Liqun Yang of Science, Northeastern University, China
Received: Dec 8, 2017
Accepted: Feb 20, 2018
Published Online: Mar 02, 2018
Authors
Hazem Dawoud; Tadeusz Malinski*
Department of Chemistry and Biochemistry, Nanomedical Research Laboratory, Ohio University, USA
Received: Jan 09, 2018
Accepted: Feb 27, 2018
Published Online: Mar 10, 2018
Authors
Ranjith Kumar Kankala
Institute of Biomaterials and Tissue Engineering, Huaqiao University, Fujian Provincial Key Laboratory of Biochemical Technology, Xiamen, China
Received: Jan 24, 2018
Accepted: Mar 02, 2018
Published Online: Mar 12, 2018
Authors
Satya Ranjan Sarker1,2; Shinji Takeoka1*
1 Department of Life Science and Medical Bioscience, Waseda University, Japan
2 Department of Biotechnology and Genetic Engineering, Jahangirnagar University, Bangladesh
Received: Mar 01, 2018
Accepted: Apr 26, 2018
Published Online: May 07, 2018
Authors
Almalki M1 ; Edward PC Lai1 *; Raymond Ko2 ; Chunsheng Li2
1 Department of Chemistry, Carleton University, Canada
2 Radiation Protection Bureau, Health Canada, Canada
Received: Mar 02, 2018
Accepted: May 07, 2018
Published Online: May 10, 2018
Authors
Cedric Hurth1,2*; Tania Contente-Cuomo3 ; Muhammed Murtaza3 ; Frederic Zenhausern1,2,3
1 Center for Applied Nanobioscience & Medicine, University of Arizona College of Medicine, USA
2 Whitespace Enterprise, USA
3 Center for Non-Invasive Diagnostics, Translational Genomics Research Institute, USA
Received: Mar 02, 2018
Accepted: May 31, 2018
Published Online: June 04, 2018
Authors
János Fent*; Susan Lakatos
Scientific Research and Laboratory Institute, Medical Centre of Hungarian Defense Forces, Budapest, Hungary
Received: Sep 17, 2018
Accepted: Oct 22, 2018
Published Online: Oct 31, 2018
Authors
Sachin Kumar Deshmukh
Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, 1660 SpringHill Avenue, USA
Received: Aug 20, 2018
Accepted: Nov 02, 2018
Published Online: Nov 06, 2018
