IMPACT FACTOR: 1.8
Short Name: J Nanomed
ISSN: 2578-8760
Publisher: MedDocs Publishers LLC
Spray drying technology has been used extensively for converting highly crystalline and high melting molecules to Amorphous Solid Dispersions (ASD) to overcome the solubility and bioavailability challenges [1].
Zinc oxide nanoparticles (ZnO-NPs) are being widely studied for biological applications due to their adjustable physicochemical characteristics and possible antibacterial and anticancer effects. However, variable toxicity results and unsolved biosafety issues preclude their clinical use.
Proteolysis Targeting Chimeras (PROTACs) discovered over 20 years ago, have been classified as molecules beyond rule of five (bRoF), meaning they do not follow the classic Lipinski’s rule of five for solubility and bioavailability [1].
Chitosan, a natural biopolymer obtained through the deacetylation of chitin, has gained significant attention due to its biodegradability, safety, and multifunctional biological properties.
As more new chemical entities are discovered with poor solubility and bioavailability, the applications of novel excipients and delivery technologies and their mechanisms by which the drug molecules are absorbed into systemic circulation, have been subject of continued interest [1].
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