IMPACT FACTOR: 1.8
Short Name: J Nanomed
ISSN: 2578-8760
Publisher: MedDocs Publishers LLC
Radiation therapy is one of the most commonly used techniques for the treatment for cancer. A major goal of radiation therapy is to damage cancer cells, while simultaneously imparting as small a radiation dose as possible to nearby healthy cells. Due to a high atomic number and the Auger effect, gold nanoparticles can significantly enhance doses of ionizing radiation. The amount of enhancement due to gold nanoparticles strongly depends upon several parameters, such as cellular uptake of nanoparticles, nanoparticles size, concentration, intracellular location and radiation energy.
This paper reviews the research progress of Mesoporous Silica Nanoparticles (MSNs) in the construction of drug carrying system in past studies. Through the design of its structure and chemical properties, drug carrying system with various functions can be prepared, which is suitable for drug sustained release system and targeted treatment of various pathological tissues, thus representing a revolutionary biological nano technology.
Poor solubility, high toxicity, nonspecific delivery and short circulating half-lives are the disadvantages of conventional drug delivery of the anticancer agents.
In the field of nanoparticle based drug delivery, controlled delivery of therapeutic compounds has been a matter of great interest. Unconcealed toxicity, poor selectivity, narrow therapeutic index, and high probability of developing drug resistance are the disadvantages of nanoparticle based chemotherapeutics.
Objective: Gold nanoparticles (GNPs) have the potential to enhance the effects of radiation therapy, using Auger electrons to cause additional damage to tumors. In this work, we explore the effect of two clinically important variables: dose fractionation and radiation energy. In clinical radiation therapy, radiation is fractionated (split into multiple sessions) and high-energy radiation is used. However, in the field of GNP research, radiation has generally been given in one session and lower radiation energies have generally been used.
In this article, we examined the surface topography and frictional characteristics (cartilage/cartilage) pair normal and osteoarthritic bovine cartilage. The amount of structured synovial fluid hydrated (lubricin-hyaluronan) complex is not enough to resist the effects of loading and friction...
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Authors
Hazem Dawoud; Tadeusz Malinski*
Department of Chemistry and Biochemistry, Nanomedical Research Laboratory, Ohio University, USA
Received: Jan 09, 2018
Accepted: Feb 27, 2018
Published Online: Mar 10, 2018
Authors
Ranjith Kumar Kankala
Institute of Biomaterials and Tissue Engineering, Huaqiao University, Fujian Provincial Key Laboratory of Biochemical Technology, Xiamen, China
Received: Jan 24, 2018
Accepted: Mar 02, 2018
Published Online: Mar 12, 2018
Authors
Satya Ranjan Sarker1,2; Shinji Takeoka1*
1 Department of Life Science and Medical Bioscience, Waseda University, Japan
2 Department of Biotechnology and Genetic Engineering, Jahangirnagar University, Bangladesh
Received: Mar 01, 2018
Accepted: Apr 26, 2018
Published Online: May 07, 2018
Authors
Almalki M1 ; Edward PC Lai1 *; Raymond Ko2 ; Chunsheng Li2
1 Department of Chemistry, Carleton University, Canada
2 Radiation Protection Bureau, Health Canada, Canada
Received: Mar 02, 2018
Accepted: May 07, 2018
Published Online: May 10, 2018
Authors
Cedric Hurth1,2*; Tania Contente-Cuomo3 ; Muhammed Murtaza3 ; Frederic Zenhausern1,2,3
1 Center for Applied Nanobioscience & Medicine, University of Arizona College of Medicine, USA
2 Whitespace Enterprise, USA
3 Center for Non-Invasive Diagnostics, Translational Genomics Research Institute, USA
Received: Mar 02, 2018
Accepted: May 31, 2018
Published Online: June 04, 2018
Authors
János Fent*; Susan Lakatos
Scientific Research and Laboratory Institute, Medical Centre of Hungarian Defense Forces, Budapest, Hungary
Received: Sep 17, 2018
Accepted: Oct 22, 2018
Published Online: Oct 31, 2018
Authors
Sachin Kumar Deshmukh
Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, 1660 SpringHill Avenue, USA
Received: Aug 20, 2018
Accepted: Nov 02, 2018
Published Online: Nov 06, 2018
