IMPACT FACTOR: 1.8
Short Name: J Nanomed
ISSN: 2578-8760
Publisher: MedDocs Publishers LLC
We have recently reported an original observation of how a specific molecular recognition between coated Polystyrene (PS) beads dispersed in solution and a solid surface can drastically change the process by which micro droplets of fluids dry. This observation simply relies on the analysis of the final dried residue on the surface, therefore involving minimal intervention by trained individuals and a minimum investment in sophisticated readout equipment. For instance, a smart phone CCD camera would suffice to provide the data required for the analysis.
Diethylenetriaminepentaacetate (DTPA) is an approved chemical agent for decorporation of internalized actinides. During a radiological or nuclear incident, inhalation of radioactive material into the lungs is one of the main paths of hazardous exposure. High affinity of DTPA toward actinides makes it a suitable actinide decorporation agent that accelerates their excretion from the human body. Polymeric nanoparticles are ideal for use in prolonging drug release, as they are biocompatible, non-toxic, and have been approved for therapeutic use by the Federal Drug Administration. Poly lactic-co-glycolic acid (PLGA) was chosen for this research as previous literature has shown that PLGA NPs would delay the drug release of other therapeutic agents.
Due to the limitations of viral vectors with regard to the cytotoxicity and immunogenicity, nonviral vectors, especially cationic liposomes, have been thoroughly investigated for gene therapy both in vitro and in vivo. In this review, the influence of structure-activity relationship of various amino acid-based cationic lipids with respect to in vitro gene delivery efficiencies has been discussed. Cationic lipids have been extensively investigated to explore the parameters responsible for influencing the gene delivery efficiencies so that lipid structures for efficient gene delivery can be designed for both in vitro and in vivo applications.
Recently, nanotechnology has garnered enormous attentiveness in medicine, as it addresses numerous issues associated with the conventional therapeutic strategies such as poor pharmacokinetics, lack of targeting ability, and systemic toxicity. Nanoparticles-based formulations have been utilized in various areas of biomedicine, which are of particular interest in drug delivery, imaging and diagnostic platforms, implants, vaccines, and tissue engineering due to their attractive physicochemical properties and biocompatibility. Herein, this article focuses on the insights concerning the impact of nanotechnology on the development of pharmaceutical products, which will emerge as a next-generation therapeutic platform and are envisioned to have a potential impact on public health.
A dysfunctional endothelium is the first step toward many diseases of modern civilization, including hypertension, coronary atherosclerosis, diabetes, obesity, heart failure, as well as aging. The development of new nanomedical devices and nanosensors allows in situ monitoring and measuring of the molecular processes in a single endothelial cell. It appears that the first step in triggering the dysfunction of endothelial cell is diminishing the release of cytoprotective molecule nitric oxide (NO).
In recent years, responsive nano-drug delivery systems have been extensively studied for cancer therapy due to their enhanced permeability and retention effect. In this review, we discuss recent advances in the development of responsive nano-drug delivery systems that are able to control drug biodistribution in response to specific stimuli, either exogenous (variations in temperature, magnetic field or light) or endogenous (changes in pH or enzyme concentration).
Upconverting Nanoparticle (UCNP) has recently received many attentions from theranostics and nanomedicine fields because it can be designed for multi-functional targeted nanomedicines with multi-modal imaging. One of popular UCNPs is NaLnF4: Yb,Er/Tm, which absorbs infrared and releases visible or ultraviolet light to trigger drug release or to produce singlet oxygen for therapy.
Taking advantage of their enhanced permeability and retention (EPR) effect, nanomedicines have been extensively studied for targeted drug delivery to tumor tissues. However, tumor heterogeneity restricts the EPR effect and drug penetration into tumors, and nano-formulations only generate a limited therapeutic improvement in clinical settings. Macrophages have the inherent ability of tumor homing, stealth in blood circulation, and phagocytosis of particles.
In the last 25 years a new class of nanostructured materials has overwhelmingly made its way into the biomedical field. Polyhedral Oligomeric Silsesquioxanes (POSS)s which, thanks to their hybrid nature (organic-inorganic), are materials with both high mechanical strength and biocompatibility. These characteristics, and others, make them ideal candidates for the most varied applications in medicine. This short review traces the aspects of the main recent applications.
The design and engineering of advanced nanostructures could allow for the development of novel medical tools useful for earlier diagnosis, more individualized treatment options, and better therapeutic strategies. Nanotechnology researchers are working on a number of different manufacturing techniques to combine organic and inorganic matrixes to biological molecules for regenerative medicine or delivery medication. In this frame, electrospinning is widely investigated to realize 3D fibrous organic, inorganic or composite nanostructures.
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Authors
Irene Bonadies
Institute of Polymers, Composites and Biomaterials (IPCB) – CNR, Pozzuoli, Italy
Received: Dec 20, 2017
Accepted: Jan 12, 2018
Published Online: Jan 18, 2018
Authors
Ignazio Blanco
Department of Civil Engineering and Architecture, University of Catania, Catania, Italy
Received: Nov 13, 2017
Accepted: Jan 15, 2018
Published Online: Jan 18, 2018
Authors
Xuanrong Sun*; Dabu Zhu; Yue Cai
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China
Received: Dec 27, 2017
Accepted: Jan 22, 2018
Published Online: Jan 24, 2018
Authors
Ilkeun Lee
Department of Chemistry, University of California, Riverside, USA
Received: Jan 04, 2018
Accepted: Jan 26, 2018
Published Online: Feb 14, 2018
Authors
Liqun Yang1 *; Zhipeng Hou2
1 Key Laboratory of Reproductive Health and Medical Genetics, National Health and Family Planning Commission, China
2 Center for Molecular Science and Engineering, College Liqun Yang of Science, Northeastern University, China
Received: Dec 8, 2017
Accepted: Feb 20, 2018
Published Online: Mar 02, 2018
Authors
Hazem Dawoud; Tadeusz Malinski*
Department of Chemistry and Biochemistry, Nanomedical Research Laboratory, Ohio University, USA
Received: Jan 09, 2018
Accepted: Feb 27, 2018
Published Online: Mar 10, 2018
Authors
Ranjith Kumar Kankala
Institute of Biomaterials and Tissue Engineering, Huaqiao University, Fujian Provincial Key Laboratory of Biochemical Technology, Xiamen, China
Received: Jan 24, 2018
Accepted: Mar 02, 2018
Published Online: Mar 12, 2018
Authors
Satya Ranjan Sarker1,2; Shinji Takeoka1*
1 Department of Life Science and Medical Bioscience, Waseda University, Japan
2 Department of Biotechnology and Genetic Engineering, Jahangirnagar University, Bangladesh
Received: Mar 01, 2018
Accepted: Apr 26, 2018
Published Online: May 07, 2018
Authors
Almalki M1 ; Edward PC Lai1 *; Raymond Ko2 ; Chunsheng Li2
1 Department of Chemistry, Carleton University, Canada
2 Radiation Protection Bureau, Health Canada, Canada
Received: Mar 02, 2018
Accepted: May 07, 2018
Published Online: May 10, 2018
Authors
Cedric Hurth1,2*; Tania Contente-Cuomo3 ; Muhammed Murtaza3 ; Frederic Zenhausern1,2,3
1 Center for Applied Nanobioscience & Medicine, University of Arizona College of Medicine, USA
2 Whitespace Enterprise, USA
3 Center for Non-Invasive Diagnostics, Translational Genomics Research Institute, USA
Received: Mar 02, 2018
Accepted: May 31, 2018
Published Online: June 04, 2018
Authors
János Fent*; Susan Lakatos
Scientific Research and Laboratory Institute, Medical Centre of Hungarian Defense Forces, Budapest, Hungary
Received: Sep 17, 2018
Accepted: Oct 22, 2018
Published Online: Oct 31, 2018
Authors
Sachin Kumar Deshmukh
Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, 1660 SpringHill Avenue, USA
Received: Aug 20, 2018
Accepted: Nov 02, 2018
Published Online: Nov 06, 2018
