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Influence of age on arsenic-induced mitochondrial oxidative stress in rat brain regions: Chelation with monoisoamyl 2,3-dimercaptosuccinic acid

Ram Kumar Manthari*; Kavitha Vonteru; Chiranjeevi Tikka; Rajarami Reddy Gottipolu

    This study was aimed to determine the influence of age on arsenic (As, 10mg/kg body weight given through oral gavage) induced mitochondrial oxidative stress in three different age groups of rats; young (PND21), adult (3 months) and aged (18 months) animals at seven days post-acute exposure. Further, we also evaluated the protective effect of chelating agent, monoisoamyl 2,3-dimercaptosuccinic acid (MiADMSA, 50mg/kg body weight given through oral gavage, 2 h after As administration), against As-induced perturbations in brain regions (cerebral cortex, cerebellum and hippocampus).

Comparison of time frame critical for feed supplementation on haematological indices of azawak cattle breed in semi–arid zone of Nigeria Republic

Alassan NA*; Muhammad IR; Maigandi SA; Issa S

    The hematological parameters of apparently healthy of Azawak cattle breed consisting of 36 animals (18 males and 18 females) at CERRA, Maradi in semi–arid zone in Niger Republic were studied. Data were analyzed for the effect of the time frame critical for utilization of feed supplement per sex. According a time frame critical for utilization of feed supplementation (male and female) higher and lower values of packed cell volume (PCV) was obtained from T5 (26.32±3.78%) and T1 (23.44±4.26%), there was no significantly lower (P>0.05) for Azawak cattle breed in semi–arid zone.

Advent of selfhood

Sue Savage-Rumbaugh*; Itai Roffman

    The self-evident physical similarities between human and nonhuman apes [1,2] have long fascinated us. When confronted with living gorillas and no bars, we are literally unable to take our eyes off them. Hence we pay thousands of dollars and hike steep slopes to encounter them with no bars between us. And these experiences change many who engage in them.

Screening and isolation of broadly neutralizing HIV-1 antibodies

Zehua Sun

    Passive immunization for prevention and treatment of HIV-1 infection still plays important roles in fighting against HIV/AIDS. Recently, a panel of potent broadly neutralizing antibodies (bnAbs) against HIV-1 has been isolated. These potent antibodies are considered of promise in passive therapeutic treatment and the guidance of vaccine design. In this brief review, current techniques in monoclonal antibody screening and isolation

Recombinant subunit vaccines against Toxoplasma gondii: Successful experimental trials using recombinant DNA and proteins in mice in a period from 2006 to 2018

Ragab M Fereig; Hanan H Abdelbaky; Adel Elsayed Ahmed Mohamed; Yoshifumi Nishikawa*

    Development of potent and safe vaccines is the utmost goal for all vaccinologists worldwide. Toxoplasmosis is a zoo notic disease affecting almost all the warm-blooded animals and caused by the intracellular protozoan parasite Toxoplasma gondii. Up to date, neither potent nor broad spectral vaccine against vulnerable hosts to T. gondii is available.

Partial replacement of alfalfa hay by wheat straw improves milk oxidative stability without negative effects on milk yield and composition in sheep

PE Simitzis*; A Chazlari; MA Charismiadou; M Goliomytis; SG Deligeorgis

    Objective: Milk is susceptible to oxidation and the products of this process may be harmful for living organisms. Diet composition of dairy animals can influence milk fatty acid profile and therefore milk vulnerability to oxidation. The aim of the present study was to highlight the effects of partial replacement of alfalfa hay by wheat straw on milk yield, composition and oxidative stability in sheep.

Generation and characterization of a monoclonal antibody against pseudorabies virus glycoprotein C

Ying Wang; Dingding Zheng; Juan Wang; Chenyu Bai; Tongyan Wang; Zhe Sun; Xuefeng Li; Xiangdong Li; Junhua Deng*; Kegong Tian*

    Pseudorabies Virus (PRV) glycoprotein C (gC) expressed by baculovirus expression system was used to immunize BALB/c mice. Anti-PRV gC monoclonal antibody (mAb) 1F2 was achieved and presented with different test procedures. Indirect Enzyme-Linked Immune absorbent Assay (ELISA) and western blot (WB) results showed that mAb 1F2 had good reactivity and specificity to PRV gC protein. IFA results indicated it could react with PRV vaccine, classical and current epidemic strain.

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