IMPACT FACTOR: 1.3
Short Name: J Tuberc
ISSN: 2640-1193
Publisher: MedDocs Publishers LLC
The impact of COVID-19 on the diagnosis and management of tuberculosis (TB) patients is evolving. The triple burden of COVID-19, Tuberculosis, and Human Immunodeficiency Virus (HIV) is one of the major global health challenges of the twenty-first century. Nigeria ranks 10th among the 22 high-burden TB countries in the world. ...
India has experienced a notable surge in refugee populations from neighboring states, driven by conflicts, persecution, and natural disasters. Residing in temporary settlements, these refugees face a myriad of health challenges, including a heightened susceptibility to Tuberculosis (TB) infection. ...
The diagnosis of tuberculous pleurisy remains difficult because of its paucibacillary character. Several authors have studied the usefulness of IGRAs in the early diagnosis of tuberculous pleurisy, whereas these tests are designed for the detection of latent tuberculosis infection. ...
Background: Drug Induced Hepatitis (DIH) is a serious adverse effect caused by Anti-Tubercular (ATT) drugs. The prevalence of DIH is much higher in developing countries owing to a higher prevalence of pre-existing chronic illnesses like acute or chronic liver disease and viral hepatitis; alcoholism; malnutrition; indiscriminate drug use; and a higher prevalence of advanced and drug-resistant TB requiring long-term treatment. ...
A 27-year-old male presented with lower back pain, dysuria, fatigue, night sweats, fever, and substantial weight loss during the preceding months. His medical history includes pulmonary tuberculosis. A CT scan was ordered to rule out some usual causes of renal colic, namely nephrolithiasis. ...
The upsurge of Antimicrobial Resistance (AMR) has reignited interest in bacteriophages as an alternative to antibiotics. M. tuberculosis is genetically not diverse, and standard phages do not yet target it The genome of human-adapted M. tuberculosis is substantially smaller than that of its environmental progenitors...
Despite the ongoing efforts of the End Tb strategy by the United Nations Sustainable Development Goals (UNSDG) by 2025, Tuberculosis (TB) was regarded as one of the most problematic infectious disease of international concern prior to the advent of Coronavirus Disease 2019 (COVID-19). The global TB report for 2021 emphasizes that we stand at a road...
Tuberculosis (TB) is a curable illness, caused by, Mycobacterium Tuberculosis (Mtb), is still significant. Technological progress in TB treatment has been limited. The major therapeutic technique to treat the condition is first line anti-tuberculosis drugs (A fixed-dose, single-tablet combination of four drugs: Rifampin, isoniazid, pyrazinamide, and ethambutol) with almost an efficacy of 95% in susceptible individuals...
The WHO classifies urogenital tuberculosis as a severe type of TB that can be complicated by serious functional sequelae and occasionally necessitates surgical treatment. We provide a clinical case of a purulent right testicular TB melt managed by a right Orchidectomy and continued anti-tuberculosis medication, with a successful outcome (clinical and paraclinical with normal scrotal ultrasound as well as spermogram)...
Tuberculosis (TB) is a common cause of deaths in children in developing countries and TB endemic regions. Miliary TB accounts for 5% of the cases and represents disseminated TB with miliary shadows on Chest X- Ray (CXR). It occurs mainly in infants and children with non-specific features and a high mortality rate despite available treatment. BCG vaccination tends to protect against the disease and reduce its incidence...
Due to the COVID-19 pandemic, borders were closed in March 2020 to alleviate the health crisis and prevent further transmission and impact at the international level. This not only had economic consequences, but in border cities such as Melilla (Spain) the implications were also social. Under this situation, humanitarian settlements were created for people who could not return to their places of origin in Morocco...
Objective: Tuberculosis (TB) is a major public health concern globally. This study aimed to evaluate the survival and the prognostic factors of TB patients after the diagnosis of TB at two tertiary centers in Kedah, Malaysia.
Methods: This was a retrospective cohort study conducted at the two public tertiary centers. All adult patients above 18 years who were first clinically diagnosed with TB and hospitalized between January 2008 and December 2011 were included...
Tuberculosis is a communicable disease spread from one person to another; it is caused by Mycobacterium tuberculosis. It’s a very dangerous bacterial infection liable for severe increase in death cases. It’s a chronic granulomatous infectious disease. Infection happens via aerosol and inhalation of some droplets containing mycobacteria bacilli. The disease also affects animals like cattle; this is often referred to as bovine tuberculosis, which can sometimes be communicated to man...
Tuberculous meningitis develops when granulomas formed by bacillus release their content in the subarachoid space, triggering an inflammatory activity. After beginning treatment with anti-tuberculosis drugs, some patients may have a paradoxical reaction which has different clinical manifestations. Here we present a case of a severe acute encephalomyelitis. A 38-years-old female presented with refractory headache.
Tuberculosis is a major cause of morbidity and mortality globally. Infections caused by different mycobacteria can be clinically indistinguishable but the differences in their pathological features and mortality are unclear. To evaluate the contribution of different mycobacterial pathogens to lethal mycobacterial disease and assess subsequent pathological features, we performed autopsies of 49 patients with suspected TB.
Keeping in view, the peculiar attributes like similarity of symptoms with other respiratory diseases, Paucibacillary nature and inability of children to expectorate which make diagnosis of Pediatric Tuberculosis (TB) challenging, a study was conducted to find best available choices of diagnostic tests for early case detection of childhood TB particularly MDR TB.
India has the dubious distinction of being the country with the highest quantum of multidrug-resistant (MDR) tuberculosis (TB) cases worldwide. The World Health Organization (WHO) in 2016 recommended a shorter drug regimen for patients with MDR TB or Rifampin(R) resistant TB who had no past history of receiving second-line drugs (SLDs) and in whom resistance to fluoroquinolones (FQ) and Second Line Injectables (SLI) has been ruled out or was considered highly unlikely.
Genitourinary Tuberculosis (GUTB) is the second most common form of extrapulmonary TB after lymph nodes. Extensive tubercular involvement of urinary tract may lead to auto-nephrectomy, pan-ureteral strictures, thimble bladder and rarely urethral strictures or a combination of these. Management of cases with involvement of multiple strictures at multiple sites is challenging.
Direct sputum smear microscopy remains the most cost-effective tool for tuberculosis diagnosis and treatment monitoring in resource constrained settings. Random blinded rechecking is a reliable tool to measure and improve smear microscopy. So, this study was intended to assess random blinded rechecking of AFB smear microscopy performance in selected private health facilities in Tigray region, Northern Ethiopia.
Tuberculosis is a chronic airborne and infectious disease which remains a leading cause of death in people living with Human Immunodeficiency Virus (HIV). Globally in 2018, there were 251,000 documented cases of death in HIV positive people. Timely diagnosis of tuberculosis and detection of drug resistance to TB drugs in such patients remains a challenge because of non specific presentation and disseminated nature of the disease.
Worldwide tuberculosis was top ten cause of death alongside, Human Immunodeficiency Virus (HIV) in 2018; 10.0 million people became ill with tuberculosis with 1.2 million deaths occurring among HIV negative people while an additional 251,000 were HIV positive. Isoniazid preventive therapy (IPT), intensified case finding, and infection control have been widely recommended to reduce the burden of TB in people living with Human Immunodeficiency Virus (PLHIV).
The aim of the present study was to design mannose anchored rifampicin nanostructured lipid carrier for active targeted drug delivery to alveolar macrophages. Targeting ligand, N-octadecyl-mannopyranosylamine was synthesized and characterized. Rifampicin loaded nanostructured lipid carriers were composed of stearic acid, oleic acid and targeting ligand and were prepared by melt homogenization ultrasonication.
In April 2018, a 63-year-old patient was admitted due to general fatigue, dyspnea and continuous pyrexia. He was previously treated for several weeks with intravesical BCG for a bladder carcinoma. Chest computed tomography scan revealed bilateral miliary nodules. Microbiological findings including acid fast staining and urine cultures were all negative...
Introduction: With 20% cases, India accounts for the highest tuberculosis burden in the world. Tuberculous lymphadenitis is the most common form of extrapulmonary tuberculosis in India. Aim of this study is to present our experience on tuberculous cervical lymphadenitis.
Objective: This study aimed to ascertain the prevalence of TB among DM patients as well as factors influencing the co-morbidity. Methods: A cross-sectional study was conducted under routine programme settings in ten purposively selected health facilities in 6 states in southern Nigeria in 2018. Over a period of six months, all diagnosed DM cases aged ≥18years who attended the clinics were progressively screened for tuberculosis.
Abscesses that are enclosed within the bony cage of the skull or spinal column can expand to compress the brain or spinal cord and cause severe symptoms, permanent complications, or even death. Prompt diagnosis and proper treatment can avert complications and achieve cure in many cases. Tuberculosis is one of the rare cause of the brain abscess. Both the diagnosis and management of abscess..
Purpose:Tuberculosis (TB) still constitutes a major public health challenge due to its high mortality and morbidity rates [1]. In 2017, 10.4 million people contracted the disease and 1.8 million died from it. More than 95% of tuberculosis deaths occur in low and middle income countries...
Purpose: Bovine Lymphocyte Antigen-DRB3.2 (BoLA-DRB3.2), plays a critical role in immunologic function. This study focuses on the variations of BoLA-DRB3.2 Gene in Chinese Holstein of dairy cattle and their relationship to tuberculosis susceptibility.
Objective: To compare the cost-effectiveness of 2 treatment schemes for tuberculosis in Mexico, before and after the implementation of fixed-dose combination (FDC).
Material and methods: Model of economic evaluation based on information posted for 2014 cohort. The results and costs of drugs in both scenarios (1 = prior to 2006, single tablets; 2 = after to 2006, FDC) were evaluated using a decision tree model.
The present article describes epidemiologic indices for tuberculosis and some other infectious and cardiometabolic disorders, performing regional and chronologic comparisons in Southern region of Brazil, as well as international comparisons with Chile. The data obtained show that at least in populations studied, tuberculosis and HIV/AIDS are disorders belonging to intermediate age categories with male predominance, in contrast to septicemia and cardiometabolic diseases. It is suggested that partially tuberculosis may be a consequence of HIV / AIDS.
Cavitatory pulmonary tuberculosis is a rare entity in children especially in infants. Tuberculomas in brain is rarer in infants and children. Concurrent occurrence of multiple brain tuberculomas and miliary tuberculosis with cavitatory pulmonary tuberculosis is an extremely rare phenomenon. We present an infant with these rarities.
Objective: Tuberculosis (TB) is a public health concern worldwide. Multifocal Tuberculosis (MFT) is a severe disease and relatively an unusual form of TB. We aimed to identify the epidemiological and evolutionary characteristics of MFT in Southern Tunisia and to analyse its chronological trends between 1995 and 2016. Methods: We conducted a retrospective study from January 1995 to December 2016 in South of Tunisia including all new TB cases. MFT was defined as concurrent tubercular involvement of two or more non-contiguous organs.
Poor compliance to anti-tuberculosis treatment is sometimes related to its adverse effects. By reporting any unusual or severe treatment related accident, we try to enlarge our background in order to manage better any similar case.
Tuberculosis and tobacco smoking are two major public health problems which are causing a heavy mortality worldwide. Tobacco smoke increases the risks of Mycobacterium tuberculosis infection, of severe TB and death from TB. In emerging countries, quitting smoking is a means of controlling the TB epidemic. Smokers with TB are less compliant with TB medications, justifying smoking cessation support. Helping to quit smoking increases adherence to treatment of tuberculosis and tobacco abstinence rates among patients treated.
Tuberculosis continues to infect millions of people in the world each year and is the leading cause of death for people with HIV. Use of a Tuberculin Skin Test (TST) can be used to identify latent tuberculosis and to diagnose active tuberculosis disease. To assist in developing this skill a TST study tool was developed. The TST study tool has been used by various tuberculosis instructors in a mid-western state to meet the intent of providing skilled health care providers to do TST for patients entering long term care and employees in other health facilities.
Tuberculosis is one of the world's deadliest diseases and is a major global health problem. In 2016, there were an estimated 10.4 million new TB cases and an estimated 1.7 million TB deaths worldwide. The situation is further aggravated by emergence of MDR-TB and XDR-TB. In 2016, United Nations adopted a new set of goals, known as the Sustainable Development Goals (SDGs) to end TB. Ending TB by 2030 is a target of the SDGs and the goal of the End TB Strategy. WHO has set a target of 95% reduction in deaths and a 90% decline in TB incidence by 2035. WHO calls on all governments, communities, civil society, and the private sector to "Unite to End TB. Ending TB can be achieved with greater collaboration within and across governments.
With the emergence of multiple-drug resistant bacteria pathogens, it has become increasingly important to develop new strategies for exploring alternative drug targets and new bactericides. However, new drug targets with a different antimycobacterial spectrum than current clinical drugs are lacking. In this study, based on a transcriptional regulation (TR) network of Mycobacterium tuberculosis, more than 60 higher in-degree proteins (HidPs) from the network were first characterized.
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