Current Edition

Magnetic resonance imaging to assess fibrosis in chronic kidney disease

Jiong Zhang

    Chronic kidney disease (CKD) is a major public health problem. Accumulating evidence suggests that a key contributor to the progression of nearly all forms of CKD is fibrosis. Multiple physical changes occur in the fibrotic kidney, such as 1) reduced capillary density, 2) dilated and atrophic tubules, 3) increased interstitial extracellular matrix, and 4) hypoxia.

Renal FGFR1 signaling and blood pressure regulation

Xiaobin Han

    FGF-23 is a bone-derived hormone that regulates phosphate and vitamin D homeostasis through activation of FGFR/α-Klotho binary receptor complexes in the kidney. The association between elevated circulating FGF-23 concentrations and increased cardiovascular mortality, particularly in chronic kidney disease (CKD), has brought new interest in understanding FGF-23's on-target and off-target cardiovascular actions.

Incidence of proteinuria following gemcitabine administration is a likely sign of poor outcome for cancer patients

Masaki Hara*, Yuki Nishizawa, Teruhiro Fujii, Masamitsu Ubukata, Akihito Ohta, Kosaku Nitta

    It is well known that gemcitabine (GEM) rarely causes thrombotic microangiopathy. However, the prevalence and clinical significance of incident proteinuria among cancer patients after GEM administration are not fully understood.

Does indomethacin exposure increase risk for chronic kidney disease in very low birth weight infants?

Amy C Blake, Katja M Gist, Claire Palmer, Danielle E Soranno*

    To determine the association between indomethacin exposure and risk for chronic kidney disease defined by hypertension in very low birth weight (VLBW) infants.

A successful strategy for achieving minimal cold ischemia time for Donation after Circulatory Death in Belfast City Hospital

Mahendra N Mishra*; Aisling Courtney; Bernadette Magee; Miceal Cole; Ashley Meenagh; Jeanie Martin

    Belfast is the sole renal transplant centre in Northern Ireland (population 1.8 million) and the local Histocompatibility & Immunogenetics laboratory supports approximately 120 transplants annually. Donation after Circulatory Death (DCD) donor organs have been used in this centre since 2013. Such transplants have outcomes comparable to donation after brainstem death donor transplants provided the Cold Ischaemic Time (CIT) is minimised.

Potential signaling pathway and molecular mechanism of CD2AP associated with proteinuria in glomerular disease

Hongzhen Zhong; Hongyan Li; Zhiqing Zhong; Tianbiao Zhou*

    The albuminuria is the early evidence of glomerular filtration membrane damaged and increased permeability. Slit diaphragm is a most important part of selective filtration in the glomerulus. CD2 Associated Protein (CD2AP) is one of slit diaphragm molecules, which is associated with proteinuria. Continuous proteinuria increases the risk of cardiovascular event rate and mortality. Hence, we reviewed the potential signaling pathway and the molecular mechanism of CD2AP associated with proteinuria in glomerular disease.

Antihypertensive use and risk of intradialytic hypotension in hospitalized end-stage renal disease patients

Andrew Nishimoto; Benjamin T Duhart; Robert B Canada; David Shoop; Joanna Q Hudson*

    Background: Intradialytic Hypotension (IDH) is the most common complication of Hemodialysis (HD). Administration of antihypertensive medications (AHTs) in the inpatient setting often occurs before dialysis; however, the influence on the rate of IDH is unclear. This study evaluated the association of AHT, nitrates, and other factors with development of IDH in the inpatient setting.

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