IMPACT FACTOR: 1.2
Background: Hypokalemic Periodic Paralysis (HPP) is a rare muscle disorder characterized by episodic muscle weakness that can lead to respiratory failure. This disorder is a common manifestation of renal tubular acidosis. Renal tubular acidosis can occur associated with various systemic disorders such as Sjögren's syndrome and thyroid disorders. Discussion: HPP is a rare presentation in distal renal tubular acidosis secondary to Sjögren's syndrome.
Renal failure is a global medical problem responsible for 134 deaths/1000 person-year. Kidney transplant is the treatment of choice for ESRD (End Stage Renal Disease). There are many surgical and immunological challenges for kidney transplantation. One of these challenges is re-implanting the ureter of the transplanted kidney into the bladder.
Tuberculous lymphadenitis is most frequent presentation of extra pulmonary tuberculosis. Tuberculosis (TB) is responsible for up to 43% of peripheral lymphadenopathy in the developing word. The objective of this case report is to highlight the relationship between secondary amyloidosis and tuberculosis, though it was well established, it’s rarely reported due to extra pulmonary tuberculosis...
Purpose: Hyponatremia is frequently observed electrolytes derangement in both medical and surgical specialties with a variety of underlying illnesses. The rapidity of sodium derangement and symptoms at the time of presentation help to decide its management plan. Many times, treating primary disease specifically along with just conservative steps for hyponatremia i.e., plain water restriction, adding salt, or infusion isotonic saline help achieve desirable results.
Background: Renal Cell Carcinoma (RCC) is the third most common malignancy of the genitourinary system characterized by lack of early warning clinical manifestations (asymptomatic) and late triad of symptoms (flank pain, hematuria, and palpable renal mass). It accounts for approximately 2-3 % of the adult malignancy and 90% to 95% of neoplasms arising from the kidney...
An increase in the elderly population with multiple complex co-morbidities, such as atrial fibrillation, stroke or myocardial infarction and on anticoagulation, poses a challenge for urologists managing patients, especially in the perioperative period. It is therefore important for all clinicians to have a clear understanding of the mechanisms of action of common anticoagulants and their pharmacokinetics and pharmacodynamics. This article outlines the various guidelines and recommendations for anticoagulant use in the perioperative period.
Accurate measurement of Blood Pressure (BP) is crucial to the diagnosis and management of hypertensive disorders in pregnancy. Weight gain and higher Body Mass Index (BMI) is believed to increase maternal risk during pregnancy. Therefore, the present study was designed to measure the Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) among pregnant women and its association with BMI and age in Southern Nepal.
Kidney disease is a global public health problem, affecting more than 750 million people worldwide, the magnitude and impact of kidney disease are better defined in developed countries, clinical evidence suggests that in developing countries like Angola, the impact may be greater. To verify the sociodemographic conditions of Angolan patients with new pathologies after hemodialysis treatment.
To evaluate the patients that were operatively treated using retrograde intrarenal surgery (RIRS) with three same-model ureterorenoscopes by a single surgeon in a single clinic between January 1, 2013 and December 31, 2017 and to compare the treatment outcomes. The retrospective study included a total of 267 patients that underwent RIRS via three different flexible endoscopes of the same brand between January 1, 2013 and December 31, 2017.
Introduction: Few studies have tested which is the best immunosuppressive regimen for marginal kidneys. The aim of this study is to compare graft outcomes, renal function and rate of complications between a group of recipients of a kidney graft from marginal donor receiving everolimus, cyclosporine and steroids (group RAD) versus a group receiving cyclosporine, enteric coated micophenolate mofetil (group ECMPS) and steroids...
A single center retrospective study Malignancies after renal transplantation are the third cause of graft loss. In this retrospective monocentric study, we analyzed the rates of malignancies in 750 patients who received a kidney transplant in our renal unit between 1981 and 2011 and the effects of the development of the malignancies in terms of graft outcomes...
Primary hyperaldosteronism is the most frequent cause of secondary hypertension. However, it can also be found in apparently normotensive patients, often associated with recurrent hypokalemia and isolated hypertensive episodes...
Background: Intradialytic Hypotension (IDH) is the most common complication of Hemodialysis (HD). Administration of antihypertensive medications (AHTs) in the inpatient setting often occurs before dialysis; however, the influence on the rate of IDH is unclear. This study evaluated the association of AHT, nitrates, and other factors with development of IDH in the inpatient setting.
The albuminuria is the early evidence of glomerular filtration membrane damaged and increased permeability. Slit diaphragm is a most important part of selective filtration in the glomerulus. CD2 Associated Protein (CD2AP) is one of slit diaphragm molecules, which is associated with proteinuria. Continuous proteinuria increases the risk of cardiovascular event rate and mortality. Hence, we reviewed the potential signaling pathway and the molecular mechanism of CD2AP associated with proteinuria in glomerular disease.
Belfast is the sole renal transplant centre in Northern Ireland (population 1.8 million) and the local Histocompatibility & Immunogenetics laboratory supports approximately 120 transplants annually. Donation after Circulatory Death (DCD) donor organs have been used in this centre since 2013. Such transplants have outcomes comparable to donation after brainstem death donor transplants provided the Cold Ischaemic Time (CIT) is minimised.
To determine the association between indomethacin exposure and risk for chronic kidney disease defined by hypertension in very low birth weight (VLBW) infants.
It is well known that gemcitabine (GEM) rarely causes thrombotic microangiopathy. However, the prevalence and clinical significance of incident proteinuria among cancer patients after GEM administration are not fully understood.
FGF-23 is a bone-derived hormone that regulates phosphate and vitamin D homeostasis through activation of FGFR/α-Klotho binary receptor complexes in the kidney. The association between elevated circulating FGF-23 concentrations and increased cardiovascular mortality, particularly in chronic kidney disease (CKD), has brought new interest in understanding FGF-23's on-target and off-target cardiovascular actions.
Chronic kidney disease (CKD) is a major public health problem. Accumulating evidence suggests that a key contributor to the progression of nearly all forms of CKD is fibrosis. Multiple physical changes occur in the fibrotic kidney, such as 1) reduced capillary density, 2) dilated and atrophic tubules, 3) increased interstitial extracellular matrix, and 4) hypoxia.
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