Archive

Case of 50 Years Old Female with Quadriplegia and Acidosis

Dnyanesh Morkar; Priyanka Patil; Nidhi Mangalwedhe*

    Background: Hypokalemic Periodic Paralysis (HPP) is a rare muscle disorder characterized by episodic muscle weakness that can lead to respiratory failure. This disorder is a common manifestation of renal tubular acidosis. Renal tubular acidosis can occur associated with various systemic disorders such as Sjögren's syndrome and thyroid disorders. Discussion: HPP is a rare presentation in distal renal tubular acidosis secondary to Sjögren's syndrome.


Three Times Kidney Failure Leads to Multiple Kidney Transplantation in a Middle-Aged Man and the Surgical Challenges: A Case Report

Ammar Raiy; M Subhi Murad*; Humam Hamdan; Wael Nakawa

    Renal failure is a global medical problem responsible for 134 deaths/1000 person-year. Kidney transplant is the treatment of choice for ESRD (End Stage Renal Disease). There are many surgical and immunological challenges for kidney transplantation. One of these challenges is re-implanting the ureter of the transplanted kidney into the bladder.


Secondary Renal Amyloidosis Following Long Standing Tuberculosis Lymphadenitis - A Case Report

Meskelu Kidu Weldetensae*; Ephrem Berhe; Samrawit Gebremedhin Kellele; Birhanu Awtachew Kinfe

    Tuberculous lymphadenitis is most frequent presentation of extra pulmonary tuberculosis. Tuberculosis (TB) is responsible for up to 43% of peripheral lymphadenopathy in the developing word. The objective of this case report is to highlight the relationship between secondary amyloidosis and tuberculosis, though it was well established, it’s rarely reported due to extra pulmonary tuberculosis...


Hyponatremia Under Various Specialties

Shoukat Memon*; Ashar Alam; Faiza Saeed; Beena Salman; Javeria Chughtai; Salman Imtiaz

    Purpose: Hyponatremia is frequently observed electrolytes derangement in both medical and surgical specialties with a variety of underlying illnesses. The rapidity of sodium derangement and symptoms at the time of presentation help to decide its management plan. Many times, treating primary disease specifically along with just conservative steps for hyponatremia i.e., plain water restriction, adding salt, or infusion isotonic saline help achieve desirable results.


Renal Function after Partial Nephrectomy Versus Radical Nephrectomy for Renal Cell Carcinoma: A Comparative Study

Enamul Hoque*; Shamim Hossain; Mohammad Abdus Salam; Muhammed Serajul Islam; Akter kamal Perveg; Mohammad Abdus Salam; AK Al-Miraj

    Background: Renal Cell Carcinoma (RCC) is the third most common malignancy of the genitourinary system characterized by lack of early warning clinical manifestations (asymptomatic) and late triad of symptoms (flank pain, hematuria, and palpable renal mass). It accounts for approximately 2-3 % of the adult malignancy and 90% to 95% of neoplasms arising from the kidney...


Review of Perioperative Anticoagulation in Urology

Akshitha Devaraj*; Ankitha Devaraj; Shahzad Shah

    An increase in the elderly population with multiple complex co-morbidities, such as atrial fibrillation, stroke or myocardial infarction and on anticoagulation, poses a challenge for urologists managing patients, especially in the perioperative period. It is therefore important for all clinicians to have a clear understanding of the mechanisms of action of common anticoagulants and their pharmacokinetics and pharmacodynamics. This article outlines the various guidelines and recommendations for anticoagulant use in the perioperative period.


Blood Pressure Measurement among Women of Reproductive Age in Southern Nepal

Satyam Prakash*; Dipendra Raj Pandeya; Jitendra Kumar Singh; Khushbu Yadav

    Accurate measurement of Blood Pressure (BP) is crucial to the diagnosis and management of hypertensive disorders in pregnancy. Weight gain and higher Body Mass Index (BMI) is believed to increase maternal risk during pregnancy. Therefore, the present study was designed to measure the Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) among pregnant women and its association with BMI and age in Southern Nepal.


Sociodemographic Conditions of Angolan Patients with New Pathologies After Hemodialise Treatment

Euclides Nenga Manuel Sacomboio*; Maite Zeferino Gamba

    Kidney disease is a global public health problem, affecting more than 750 million people worldwide, the magnitude and impact of kidney disease are better defined in developed countries, clinical evidence suggests that in developing countries like Angola, the impact may be greater. To verify the sociodemographic conditions of Angolan patients with new pathologies after hemodialysis treatment.


Comparison of the outcomes of retrograde intrarenal surgery performed in upper urinary tract stones of any size at any location using three same-model flexible ureterorenoscopes

Yavuz Guler

    To evaluate the patients that were operatively treated using retrograde intrarenal surgery (RIRS) with three same-model ureterorenoscopes by a single surgeon in a single clinic between January 1, 2013 and December 31, 2017 and to compare the treatment outcomes. The retrospective study included a total of 267 patients that underwent RIRS via three different flexible endoscopes of the same brand between January 1, 2013 and December 31, 2017.


Outcomes of renal transplantation from extended criteria donors in therapy with everolimus, cyclosporine and steroids versus enteric coated micophenolate sodium, cyclosporine and steroids

Carta Paolo*; Caroti Leonardo; Moscarelli Luciano; Antognoli Giulia; Di Maria Lorenzo; Lino Cirami

    Introduction: Few studies have tested which is the best immunosuppressive regimen for marginal kidneys. The aim of this study is to compare graft outcomes, renal function and rate of complications between a group of recipients of a kidney graft from marginal donor receiving everolimus, cyclosporine and steroids (group RAD) versus a group receiving cyclosporine, enteric coated micophenolate mofetil (group ECMPS) and steroids...


Malignancies after renal transplantation: A single center retrospective study

Paolo Carta*; Di Maria Lorenzo; Moscarelli Luciano; Larti Aida; Leonardo Caroti; Lino Cirami

    A single center retrospective study Malignancies after renal transplantation are the third cause of graft loss. In this retrospective monocentric study, we analyzed the rates of malignancies in 750 patients who received a kidney transplant in our renal unit between 1981 and 2011 and the effects of the development of the malignancies in terms of graft outcomes...


Intraoperative hypertensive crisis in a patient with normotensive primary aldosteronism. Lessons from a clinical case

Agnieszka Kuzior; Manuel Esteban Nivelo-Rivadeneira; Paula Fernandez-Trujillo-Comenge; Esperanza Perdomo-Herrera; Alba Lucia Tocino-Hernandez; Marta Martin-Perez; Paula Gonzalez-Diaz; Maria Victoria Sainz de Aja-Curbelo; Ana Delia Santana-Suarez; Francisco Javier Martinez-Martin*

    Primary hyperaldosteronism is the most frequent cause of secondary hypertension. However, it can also be found in apparently normotensive patients, often associated with recurrent hypokalemia and isolated hypertensive episodes...


Antihypertensive use and risk of intradialytic hypotension in hospitalized end-stage renal disease patients

Andrew Nishimoto; Benjamin T Duhart; Robert B Canada; David Shoop; Joanna Q Hudson*

    Background: Intradialytic Hypotension (IDH) is the most common complication of Hemodialysis (HD). Administration of antihypertensive medications (AHTs) in the inpatient setting often occurs before dialysis; however, the influence on the rate of IDH is unclear. This study evaluated the association of AHT, nitrates, and other factors with development of IDH in the inpatient setting.


Potential signaling pathway and molecular mechanism of CD2AP associated with proteinuria in glomerular disease

Hongzhen Zhong; Hongyan Li; Zhiqing Zhong; Tianbiao Zhou*

    The albuminuria is the early evidence of glomerular filtration membrane damaged and increased permeability. Slit diaphragm is a most important part of selective filtration in the glomerulus. CD2 Associated Protein (CD2AP) is one of slit diaphragm molecules, which is associated with proteinuria. Continuous proteinuria increases the risk of cardiovascular event rate and mortality. Hence, we reviewed the potential signaling pathway and the molecular mechanism of CD2AP associated with proteinuria in glomerular disease.


A successful strategy for achieving minimal cold ischemia time for Donation after Circulatory Death in Belfast City Hospital

Mahendra N Mishra*; Aisling Courtney; Bernadette Magee; Miceal Cole; Ashley Meenagh; Jeanie Martin

    Belfast is the sole renal transplant centre in Northern Ireland (population 1.8 million) and the local Histocompatibility & Immunogenetics laboratory supports approximately 120 transplants annually. Donation after Circulatory Death (DCD) donor organs have been used in this centre since 2013. Such transplants have outcomes comparable to donation after brainstem death donor transplants provided the Cold Ischaemic Time (CIT) is minimised.


Does indomethacin exposure increase risk for chronic kidney disease in very low birth weight infants?

Amy C Blake, Katja M Gist, Claire Palmer, Danielle E Soranno*

    To determine the association between indomethacin exposure and risk for chronic kidney disease defined by hypertension in very low birth weight (VLBW) infants.


Incidence of proteinuria following gemcitabine administration is a likely sign of poor outcome for cancer patients

Masaki Hara*, Yuki Nishizawa, Teruhiro Fujii, Masamitsu Ubukata, Akihito Ohta, Kosaku Nitta

    It is well known that gemcitabine (GEM) rarely causes thrombotic microangiopathy. However, the prevalence and clinical significance of incident proteinuria among cancer patients after GEM administration are not fully understood.


Renal FGFR1 signaling and blood pressure regulation

Xiaobin Han

    FGF-23 is a bone-derived hormone that regulates phosphate and vitamin D homeostasis through activation of FGFR/α-Klotho binary receptor complexes in the kidney. The association between elevated circulating FGF-23 concentrations and increased cardiovascular mortality, particularly in chronic kidney disease (CKD), has brought new interest in understanding FGF-23's on-target and off-target cardiovascular actions.


Magnetic resonance imaging to assess fibrosis in chronic kidney disease

Jiong Zhang

    Chronic kidney disease (CKD) is a major public health problem. Accumulating evidence suggests that a key contributor to the progression of nearly all forms of CKD is fibrosis. Multiple physical changes occur in the fibrotic kidney, such as 1) reduced capillary density, 2) dilated and atrophic tubules, 3) increased interstitial extracellular matrix, and 4) hypoxia.


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