Chronicles of Oncology

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Chronicles of Oncology

Short Name: Chronicles Oncol
ISSN: 2638-4248
Publisher: MedDocs Publishers LLC

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Current Edition

Breast and bone: A story of hidden similarities

Chiara Antonacci, Manuel Scimeca, Rita Bonfiglio, Sara Fazi, Elena Bonanno*

Several clinical and biological evidences, such as breast calcifications and breast metastasis to bone, suggest a deep relation between bone and breast tissues. Tangible proofs of great similarities between these tissues bring to light how complex phenomena, as breast micro calcifications and bone metastasis, could be the result of a tight correlation between apparently different organs.

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The role of exosomes in diagnosis of non-haematological malignancies

Dhruv Jain*, Sneha Dhariwal, Honey Sachdeva

Exosomes are nano-sized particles 'exfoliated' from a variety of cell types. They are known to facilitate exchange of messages between various cells by transporting bio-functional cargo like proteins, nucleic acids and lipids. Exosomes play a pivotal role in cellular signaling under normal physiological conditions, as well as in diseased states like cancer. They are shed in excessive amounts by cancer cells and can be harnessed from a variety of body fluids.

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A case of isolated metastasis to right level II cervical lymph node from intrahepatic cholangiocarcinoma

David Forner*; Martin Bullock; Matthew Rigby; Derek Wilke; Nathan Lamond

Cervical lymphadenopathy is a common reason for referral to the Otolaryngology – Head & Neck Surgery clinic. The differential diagnosis is broad, and can include infectious, traumatic, anatomical, and neoplastic etiologies. Cervical lymph nodes are the primary site of metastasis for head and neck cancers, but have also been implicated in other forms of cancer, including primary tumors of the lung, gastrointestinal tract, and breast.

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Risk of myocarditis in patients with cancer treated with immune checkpoint inhibitors.

Matthew Kelling MS; Michelle Dimza; Samir Dalia MD*

The field of oncology has changed immensely since the advent of immune checkpoint inhibitors (ICIs). Cancers, such as advanced melanoma, previously carried a prognosis of 8-10 months, now patients have a chance at remission [1]. In certain patient populations with advanced non-small cell lung cancer (NSCLC), ICIs are improving outcomes and becoming the standard of care [2]. The potency of these immunotherapy agents is due to their ability to disinhibit the body's immune response and unleash a vigorous antitumor response.

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How to overcome endocrine resistance in early and metastatic breast cancer

Ewelina Biskup; Marcus Vetter*

According to St. Gallen Consensus, endocrine responsive breast cancer is defined by positive steroidal receptors (ER= estrogen receptor and PR= Progesterone Receptor). ER/PR and HER2 are the most important biomarkers in decision-making about adjuvant and palliative treatment options. Available data suggest, that the higher the expression of ER and PR, the better the outcome for patients with early and advanced breast cancers.

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Global patent landscape in breast cancer metastasis

Martín Perez-Santos*; Maricruz Anaya-Ruiz

Objective: To analyse multi-source data patents, and try to draw the whole landscape of the research and development community in the field of breast cancer metastasis.

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