Short Name: Chronicles Oncol
ISSN: 2638-4248
Publisher: MedDocs Publishers LLC
Melanoma, known for its aggressive progression and metastatic potential, remains a significant therapeutic challenge. This study aimed to investigate the anti-cancer effects of human IFN-ɛ, a neotype I interferon with potential tumor-inhibiting and immune-modulating properties, on melanoma cells.
Vitamin E is a group of antioxidant to copherols and to cotrienols that have been shown to have a potential role in chemoprophylaxis. However, whether vitamin E can reduce the risk of prostate cancer remains controversial.
Although all the thyroid carcinoma are rare in young adults but the Thyroid follicular carcinoma is the rarest one. Almost 90% of thyroid carcinomas are papillary while 6% of them are the follicular. The incidence of carcinoma thyroid in people in their twenties or younger age is absolutely rare i.e. 1 in million in world wide. The case I am presenting is a juvenile thyroid follicular carcinoma showing rapid growth of a goiter.
Chemoresistance in cancer therapeutics is an emerging problem and led to relapse and poor prognosis. Development, progression, and metastasis of tumor is regulated by signaling pathways including PI3K, Akt, mTOR, NF-κB, ERK, MAPK, MEK, JAK/STAT, mTOR, HER-2, and EGFR signaling pathways. However, aberrant expression of these pathways as well as of epigenetic regulation including methylation, acetylation, microRNAs, and lncRNAs imparts chemo resistance in cancer...
Squamous Cell Carcinoma (SCC) is a type of cancer, in which, mainly, skin, mouth and esophagus are pronto being affected. As a specified type of this carcinoma, Cutaneous Squamous Cell Carcinoma (CSCC) is regarded as the second most common non-melanoma skin cancer. About 250,000 cases of CSCC, are diagnosed annually, meanwhile, statistics depict a dramatic upsurge that culminated to 5 million in 2011. Classical risk factors of CSCC comprising age, ethnicity, skin phototype, Ultraviolet (UV) exposure, and immunocompromised.
Among the various forms of cancer is penile cancer, considered as a rare neoplasm and affects 1/100,000 men in developed countries. In Brazil, these tumors correspond to 2% of malignant neoplasms in men, being five times more prevalent in the North and Northeast regions compared to other regions. Aiming to write the incidence of penile cancer in the state of Espírito Santo (ES) in the period 2000-2018.
A 35-year-old male presented with acute abdomen with intra-abdominal hemorrhage. He had bilateral cryptorchidism and infertility. Immediate laparotomy was carried out. Excision of the tumor, right hemi colectomy and peritoneal toilet was done...
Objective: To analyse multi-source data patents, and try to draw the whole landscape of the research and development community in the field of breast cancer metastasis.
According to St. Gallen Consensus, endocrine responsive breast cancer is defined by positive steroidal receptors (ER= estrogen receptor and PR= Progesterone Receptor). ER/PR and HER2 are the most important biomarkers in decision-making about adjuvant and palliative treatment options. Available data suggest, that the higher the expression of ER and PR, the better the outcome for patients with early and advanced breast cancers.
The field of oncology has changed immensely since the advent of immune checkpoint inhibitors (ICIs). Cancers, such as advanced melanoma, previously carried a prognosis of 8-10 months, now patients have a chance at remission [1]. In certain patient populations with advanced non-small cell lung cancer (NSCLC), ICIs are improving outcomes and becoming the standard of care [2]. The potency of these immunotherapy agents is due to their ability to disinhibit the body's immune response and unleash a vigorous antitumor response.
Cervical lymphadenopathy is a common reason for referral to the Otolaryngology – Head & Neck Surgery clinic. The differential diagnosis is broad, and can include infectious, traumatic, anatomical, and neoplastic etiologies. Cervical lymph nodes are the primary site of metastasis for head and neck cancers, but have also been implicated in other forms of cancer, including primary tumors of the lung, gastrointestinal tract, and breast.
Exosomes are nano-sized particles 'exfoliated' from a variety of cell types. They are known to facilitate exchange of messages between various cells by transporting bio-functional cargo like proteins, nucleic acids and lipids. Exosomes play a pivotal role in cellular signaling under normal physiological conditions, as well as in diseased states like cancer. They are shed in excessive amounts by cancer cells and can be harnessed from a variety of body fluids.
Several clinical and biological evidences, such as breast calcifications and breast metastasis to bone, suggest a deep relation between bone and breast tissues. Tangible proofs of great similarities between these tissues bring to light how complex phenomena, as breast micro calcifications and bone metastasis, could be the result of a tight correlation between apparently different organs.
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Authors
Chiara Antonacci1 ; Manuel Scimeca2,3,4; Rita Bonfiglio5 ; Sara Fazi5 ; Elena Bonanno1,5*
1IRCCS Neuromed Lab. “Diagnostica Medica” and “Villa dei Platani”, Avellino, Italy
2Department of Biomedicine and Prevention, University of Rome “Tor Vergata”; Via Montpellier 1, Rome 00133, Italy
3IRCCS San Raffaele, Via di Val Cannuta 247, 00166, Rome, Italy
4OrchideaLab S.r.l., Via del Grecale 6, Morlupo, Rome (RM), Italy
5Department of Experimental Medicine and Surgery, University “Tor Vergata”, Via Montpellier 1, Rome 00133, Italy
Received: Jan 31, 2018
Accepted: Feb 16, 2018
Published Online: Feb 23, 2018
Authors
Dhruv Jain*; Sneha Dhariwal; Honey Sachdeva
Department of Oncopathology, Delhi State Cancer Institute, Delhi, India
Received: Jan 27, 2018
Accepted: Feb 26, 2018
Published Online: Mar 08, 2018
Authors
David Forner1 *; Martin Bullock2 ; Matthew Rigby1 ; Derek Wilke3 ; Nathan Lamond4
1Department of Surgery, Dalhousie University, Canada
2Department of Pathology, Dalhousie University, Canada
3Department of Radiation Oncology, Dalhousie University, Canada
4Department of Medicine, Dalhousie University, Canada
Received: Jan 31, 2018
Accepted: Mar 01, 2018
Published Online: Mar 10, 2018
Authors
Matthew Kelling MS1 ; Michelle Dimza1 ; Samir Dalia MD2*
1Kansas City University of Medicine and Biosciences, Kansas City, Missouri, USA
2Adjunct Clinical Assistant Professor of Hematology/Oncology, Kansas City University of Medicine and Biosciences, Joplin, Missouri, USA
Received: March 30, 2018
Accepted: June 01, 2018
Published Online: June 07, 2018
Authors
Ewelina Biskup1 ; Marcus Vetter2*
1Shanghai University of Medicine and Health Sciences, Shanghai, China
2Department of Internal Medicine, University Hospital Basel, Switzerland
Received: March 20, 2018
Accepted: June 18, 2018
Published Online: June 22, 2018
Authors
Martín Perez-Santos1,2*; Maricruz Anaya-Ruiz3
1Oficina de Comercialización de Tecnología, Centro Universitario de Vinculación y transferecnia de Tecnología, Benemérita Universidad Autónoma de Puebla, México
2Pharma Patent Consultancy, México
3Laboratorio de Biología Celular, Centro de Investigación Biomédica de Oriente, México
Received: March 15, 2018
Accepted: July 05, 2018
Published Online: July 10, 2018
