Neuromyelitis optica spectrum disorder with spinal involvement including conus medullaris lesions with anti-aquaporin-4 antibody: A pediatric case and literature review

Rania BEN AOUN; Hanene Benrhouma; Hedia Klaa; Thouraya Ben Younes*; Cyrine Drissi; Aida Rouissi; Melika Ben Ahmed; Ichraf Kraoua; Ilhem Ben Youssef-Turki

    Introduction: Neuromyelitis Optica Spectrum Disorder (NMOSD) is an inflammatory disease of the central nervous system, generally associated with Anti-Aquaporin-4 (AQP4) antibody. It is characterized by severe attacks of optic Neuritis (ON) and Longitudinally Extensive Transverse Myelitis (LETM). Classically, it tends to spare the conus medullaris...

Prevalence of anti-cyclic citrullinated peptide antibodies in juvenile idiopathic arthritis in Benin

Zomalheto Zavier; Assogba Michee; Zannou Vanessa; Zohoun Lutecia

    Introduction: The diagnosis of Juvenile Idiopathic Arthritis (JIA) is difficult in sub-Saharan countries due to the complexity and polymorphism of the disease. JIA can be accompanied by the presence of Anti-Cyclic Citrullinated Peptide Antibodies (ACPA). This work aims to determine the prevalence of ACPA among children suffering from juvenile idiopathic arthritis in Benin....

Examining the association of right ventricular dysfunction with moderate to severe bronchopulmonary dysplasia in preterm infants

Wisam Muhsen

    Over the last three-and-a-half decades, many advances have been made in the care of preterm infants. Some of the most important developments have been in hemodynamic management, including the use of functional echocardiography exams. The Right Ventricle (RV) functional assessment has enabled investigators to track cardiac maturational changes in the first few months of life of Very and Extremely Preterm Infants (VEPIs)...

Hazardous hyperbilirubinemia in a neonate with novel homozygous biallelic GSR (glutathione reductase) mutations

Robert D Christensen*; Peter H Grubb; Hassan M Yaish

    A six-day-old term male presented to our hospital emergency department with a total serum bilirubin (TSB) of 34.8 mg/dL. Double volume exchange transfusion resulted in a fall to 20.6 mg/dL, and intensive phototherapy resulted in a gradual further fall to 5.4 mg/dL by discharge home eight days later. This was the first child of a consanguineous couple from Southern India, with no family history of anemia or jaundice. Extensive evaluation for the etiology of the hyperbilirubinemia revealed homozygous biallelic mutations in GSR, the gene encoding Glutathione Reductase and the heterozygous polymorphism UGT1A1*28....

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