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Novel Classification of Ovarian Cancer Based on Transcription Factors That Are Closely Associated with Ovarian Development, Differentiation, and Growth

Mitsumasa Osakabe; Noriyuki Yamada; Hiroaki Itamochi; Tsukasa Baba; Noaki Yanagawa; Tamotsu Sugai*

    The traditional classification of Ovarian Cancer (OC), which includes High-Grade Serous Carcinoma (HGSC), Endometrioid Carcinoma (EC), Clear Cell Carcinoma (CCC), and Mucinous Carcinoma (MC), has been used worldwide....


Staged Procedure with Temporary Abdominal Closure in Gynaecologic-Oncology Patients in Prevention of Abdominal Compartment Syndrome: A Lesson to be Learnt

Monica Shi Qi Chua*; Ravichandran Nadarajah

    Abdominal Compartment Syndrome (ACS) is a medical emergency-characterized by organ dysfunction which is caused by intra-abdominal hypertension. Clinical signs are often non-specific and it is associated with high rate of mortality and morbidity when it is not recognized and managed promptly. Although ACS has not been commonly observed in gynaecological patients, it remains a potential risk especially in gynaecologic-oncology patients – many of whom will require extensive debulking surgery...


Gynecologic Cancer: Types, Causes and Therapeutic Approaches

Sadiya Zaki; Sibi G*

    Inflammatory ovarian masses may be difficult to distinguish preoperatively from ovarian malignancies. We present a case of a 54-year old woman with an ovarian mass, diagnosed during a COVID 19-infection. She underwent surgery because of pain and a challenging differential diagnosis on imaging. The frozen section was inconclusive and the final pathological examination showed no malignancy but only an inflammatory mass.


Case report: An Ovarian Inflammatory Mass, Possibly Related to a Recent COVID-19 Infection

Stefan Timmerman; Anne-Sophie Van Rompuy; Christophe Deroose; Vibeke Vergote; Raphaëla Dresen; Ignace Vergote; Thomas Tousseyn; Els Van Nieuwenhuysen; Jonas Yserbyt; Wouter Froyman; Toon Van Gorp

    Inflammatory ovarian masses may be difficult to distinguish preoperatively from ovarian malignancies. We present a case of a 54-year old woman with an ovarian mass, diagnosed during a COVID 19-infection. She underwent surgery because of pain and a challenging differential diagnosis on imaging. The frozen section was inconclusive and the final pathological examination showed no malignancy but only an inflammatory mass. Further extensive investigations revealed sarcoidosis, associated with a specific inflammatory changes...


Maximizing Screening for Cervical Cancer

Victor Manuel Vargas Hernandez

    Since the introduction of cytology or Pap test (Pap) in 1943, the cervicovaginal Pap has been used as the standard screening test for cervical cancer and its dissemination contributed to the reduction of incidence and mortality for cervical cancer worldwide, the incidence of cervical cancer has steadily declined, cases of deaths related to cervical cancer, are reported every year due to false negative results. Therefore, new detection methods have been proposed. LiquidBased Cytology (LBC) was introduced in 1996 to overcome the limitations of conventional Pap tests.


Pelvic Lymphocele Enlargement after Manual Lymph Drainage: Case Report and Literature Review

Jaqueline Munaretto Timm Baiocchi*; Larissa L Campanholi; Glauco Baiocchi

    Purpose: Lymphocele is a cystic cavity with a fibrous capsule that contains lymphatic fluid. Our objective is to describe physical therapy approach for leg lymphedema after endometrial cancer treatment that resulted in an increase of a pelvic lymphocele.
Client description: A 59-year-old woman with endometrial high-grade adenocarcinoma was referred to our center with a history of pelvic and leg lymphedema followed by a pelvic lump, subsequently diagnosed as pelvic lymphocele.


Intraperitoneal Chemotherapy after Cytoreductive Surgery Improves Survival in Epithelial Ovarian Cancer: A Systematic Review and Meta-Analysis

Mercedes Jimenez-Heredia*; Jose A Perez-Fidalgo; Maria Morales-Suarez-Varela; Andres Cervantes

    Introduction: Despite the magnitude of improvement in Overall Survival (OS) obtained in the GOG172, Intraperitoneal Chemotherapy (IPC) in advanced Epithelial Ovarian Cancer (EOC) has not been widely accepted as a standard procedure due to toxic effects. This together with negative results in recent Randomized Clinical Trials (RCTs) suggested a need for this meta-analysis.


The effect of omega-3 capsules on vasomotor disturbances induced by tamoxifen in breast cancer patients: A double-blind controlled clinical trial

Rezvan Heidari; Sara Azima*; Maasumeh kaviani; Sedigheh Tahmasebi

    Background and objectives: Vasomotor disturbances are among the most important side effects of tamoxifen. It is the most widely used anti-cancer drug in the world which may affect the quality of life. This study aimed to investigate the effect of omega 3 on vasomotor disturbances in women taking tamoxifen for breast cancer.


Incidence of unexpected significant pathology in morcellated uterine specimens

Sherine Salama; Nadia Ismiil; Matthew Cesari; Fang-I Lu; Elzbieta Slodkowska; Valerie Dubé; Guangming Han; Mark Marcus; Ivy Heung; Mahmoud A Khalifa; Lilian T Gien; Sharon Nofech-Mozes*

    Study objective: To determine the frequency and outcome of significant pathology in morcellated hysterectomy and myomectomy specimens and to provide a detailed pathologic account on its relative clinical safety.
Design: This is a retrospective audit of morcellated uterine specimens where preoperative, operative, pathology, adjuvant therapy (when available) and follow up data were collected. Overt malignancy and high risk pathology cases were further analyzed.


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