Influence of age on arsenic-induced mitochondrial oxidative stress in rat brain regions: Chelation with monoisoamyl 2,3-dimercaptosuccinic acid

Ram Kumar Manthari*; Kavitha Vonteru; Chiranjeevi Tikka; Rajarami Reddy Gottipolu

    This study was aimed to determine the influence of age on arsenic (As, 10mg/kg body weight given through oral gavage) induced mitochondrial oxidative stress in three different age groups of rats; young (PND21), adult (3 months) and aged (18 months) animals at seven days post-acute exposure. Further, we also evaluated the protective effect of chelating agent, monoisoamyl 2,3-dimercaptosuccinic acid (MiADMSA, 50mg/kg body weight given through oral gavage, 2 h after As administration), against As-induced perturbations in brain regions (cerebral cortex, cerebellum and hippocampus).

Comparison of time frame critical for feed supplementation on haematological indices of azawak cattle breed in semi–arid zone of Nigeria Republic

Alassan NA*; Muhammad IR; Maigandi SA; Issa S

    The hematological parameters of apparently healthy of Azawak cattle breed consisting of 36 animals (18 males and 18 females) at CERRA, Maradi in semi–arid zone in Niger Republic were studied. Data were analyzed for the effect of the time frame critical for utilization of feed supplement per sex. According a time frame critical for utilization of feed supplementation (male and female) higher and lower values of packed cell volume (PCV) was obtained from T5 (26.32±3.78%) and T1 (23.44±4.26%), there was no significantly lower (P>0.05) for Azawak cattle breed in semi–arid zone.

Screening and isolation of broadly neutralizing HIV-1 antibodies

Zehua Sun

    Passive immunization for prevention and treatment of HIV-1 infection still plays important roles in fighting against HIV/AIDS. Recently, a panel of potent broadly neutralizing antibodies (bnAbs) against HIV-1 has been isolated. These potent antibodies are considered of promise in passive therapeutic treatment and the guidance of vaccine design. In this brief review, current techniques in monoclonal antibody screening and isolation

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