IMPACT FACTOR: 1.4
Short Name: Ann Oncol Case Rep
Publisher: MedDocs Publishers LLC
Single nucleotide polymorphisms are a sort of genetic variations, have been identified in numerous genes that linked to various cancer types. SNPs in exon regions of hub cellular of genes that influence gene expression
Chordomas are rare tumors that grow slowly, tend to recur locally and seldom metastasize. They originate from residual primitive notochordal tissues along the axial skeleton and are typically found in the sacrococcygeal region (50%), clivus (35%), and vertebral bodies (15%). The median reported survival is 6.29 years with a 10-year survival rate of 39.9%.
The relationship of mutations in the BRCA 2 gene has been established with some types of tumors, especially breast, ovarian, prostate, or pancreatic cancer. However, the relationship between the development of colorectal tumors and type of genetic alteration is not entirely clear.
Advanced laryngeal cancers are conventionally treated by total laryngectomy but surgical intervention has a profound impact on quality of life. Role of radiotherapy in laryngeal cancer with extensive extra laryngeal spread is limited. Therefore, we did a study of the case series to investigate the survival outcomes and laryngeal preservation after radical radiotherapy in advanced laryngeal carcinomas with extensive extra laryngeal spread.
With its less invasive technique and quicker recovery periods, laparoscopic surgery—also referred to as minimally invasive surgery or keyhole surgery—has completely changed the surgical sector. Significant developments in laparoscopic methods, tools, and technology in recent years have enhanced patient outcomes and broadened the scope of surgical applications.
Ovarian fibromas, the most common stromal tumor, exhibit a diverse spectrum that includes conventional fibromas, cellular fibromas, and mitotically active cellular fibromas. Fibromas are usually benign with an excellent prognosis.
An immune checkpoint inhibitor-associated vasculitis is an exceedingly rare occurrence. We describe a case of cutaneous vasculitis developing in a patient with metastatic melanoma who presented with non-classic clinical findings of tender indurated erythematous plaques with overlying scale on the bilateral shins four months after starting adjuvant nivolumab therapy.
One of the first chemotherapeutic drugs reported to exert anticancer activity 5-Fluorouracil (5-FU) has been considered for many years as the mainstay of many chemotherapy regimens for a variety of malignant tumors. Most commonly recorded side effects are my elosuppression, gastrointestinal disorders, mucositis, hand–foot syndrome and rarely cardiac toxicity.
B Cell Maturation Antigen (BCMA) targeting Chimeric Antigen Receptor T Cell (CAR-T) therapy in Relapsed Refractory Multiple Myeloma (RRMM) has improved the dismal outcomes in heavily pretreated patients [1]. Currently approved anti-BCMA CAR-T include idecabtagene vicleucel (ide-cel) and ciltacabtagene autoleucel (cilta-cel) [2-6].
Cutaneous metastases of internal malignancies are rare, but they can be the first sign of clinically silent visceral cancers, making it important for physicians to be vigilant in recognizing the possibility of visceral malignancies to the skin.
Two patients with lobular carcinoma of the breast previously treated with curative intent presented with anemia and multiple areas of bone pain. CT/PET, bone scan and a panel of laboratory tests including peripheral blood smears were not abnormal except for their CA27-29 values. Bone marrow aspirates and biopsies were performed.
Robertsonian translocations between acrocentric chromosome are the most common type of constitutional chromosome rearrangement. Frequencies of rob(14;21) ranging between 14.8 and 19.6%. However, Robertsonian translocations are very rarely observed in neoplastic condition. The current study presents a case of 37 years old female with unusual constitutional Robertsonian translocation rob(14;21) (q10:q10) with t(10;22)(p13;q12) in acute myeloid leukemia with monocytic differentiation.
We report an aggressive case of anal cancer recurrences. This 38-year-old male presented with extensive verrucous anal carcinoma extending laterally across both buttocks. He was diagnosed in May 2019 with a T3N1cM0 anal SCC. His initial treatment entailed four cycles of neoadjuvant chemotherapy with carboplatin and paclitaxel, completed in October 2019, preceded by a laparoscopic defunctioning loop colostomy.
Synchronous presentation of endobronchial metastasis from prostate cancer is exceedingly rare. We describe a case of endobronchial and bone metastasis secondary to prostate cancer in a patient who presented with pulmonary symptoms and generalized back pain. Bronchoscopy and biopsy of the endobronchial mass were performed along with immunohistochemical staining for prostate-specific antigen which confirmed the diagnosis...
Cancer is still an insurmountable problem that has a devastating impact on public health all over the world. According to estimates, there will be 26 million new cases of cancer and 17 million annual cancer deaths by the year 2030 [1]. Extreme oxidative stress, persistent inflammation, cell cycle abnormalities, aberrant proto-oncogene expression, angiogenesis disorders and other factors all contribute to the complicated and multifaceted manifestation of cancer...
Nasopharyngeal carcinoma (NPC) is a widespread malignant disease in endemic regions such as South Asia. Palpable nodal metastasis in the neck or involvement of adjacent structures and ear complaints are common presentations.
A 53 years old male presented with six months history of progressive unilateral face pain and a history of ear discharge for one month. Ultrasound examination of the neck showed multiple bilaterally enlarged lymph nodes...
The treatment of Multiple Sclerosis comprises two types of Regimens, those are Disease Modifying Drugs and Autologous Hematopoietic Stem Cell Transplantation (ASCT). ASCT has been studied in MS for more than two decades. It is a process in which normal/healthy blood stem cells of your own body replace your disease stem cells in bone marrow by using Granulocyte colony stimulating factors for stem cell mobilization, CD34 for stem cell depletion, and CY, Busulfan and Antithymocyte Globulins for ablation at the time of cell infusion...
Objective: Objective To evaluate the clinical efficacy and safety of Kanglaite (KLT) injection combined with Transcatheter Arterial Chemoembolization (TACE) in the treatment of advanced liver cancer.
Materials and methods: We searched CNKI, Wanfang Database, VIP database, China biomedical database, PubMed, Cochrane Library, and EMBASE from the establishment of the database to January 2021 to screen the clinical studies on KLT and TACE in the treatment of advanced liver cancer...
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