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Acquired Severe Factor XI Deficiency in Children: Diagnosis and Management of One Case and Literature Review

Johanna Svahn*; Angelo Claudio Molinari; Valentina Nosratian; Laura Banov

Factor XI (FXI) is a blood coagulation protease involved in the coagulation cascade, activating the Factor IX and contributing to hemostasis. Its deficiency is associated with mild to moderate bleeding manifestations that typically occur after injury, mainly in tissues containing activators of the fibrinolysis (urinary tract, oropharynx).


Diagnostic, Therapeutic and Evolutionary Aspects of Solitary Plasmacytomas in the Clinical Hematology Department of Cnts Dakar

Mohamed Keita*; Nata Dieng; Sokhna Aissatou Touré; Alioune Badara Diallo; Elimane Seydi Bousso; Serigne Mourtalla Gueye; Fatoumata Binetou Keita; Fatma Dieng; Blaise Felix Faye; Moussa Seck; Saliou Diop

Solitary plasmacytomas occur most frequently in bones, but can also be seen in soft tissues. The aim of this study was to describe the diagnostic, therapeutic and evolutionary aspects of plasmacytoma. We carried out a retrospective descriptive study from January 2017 to January 2022 in the clinical hematology department in Dakar.


Classical BCR: ABL1-Negative Myeloproliferative Neoplasms: News in the Diagnosis from the 2022 International Consensus Classification of Hematological Malignancies

Lorenzo Cirasino*; Celeste Maria Fatone

Here we report the diagnostic criteria for these diseases according to the 2022 International Consensus Classification (ICC) of Myeloid and Lymphoid Neoplasms [1-3], a major revision of the previous editions of the World Health Organization (WHO) publications on the same topic [4-12].


Systemic Cytokine Response during the Extracorporeal Circulation in Patients with Myocardial Revascularization

Milan Lazarević*; Zorica Lazarević; Mlađan Golubović; Velimir Perić; Pavle Marjanović; Vesnamarja-nović; Saša Živić; Isidora Milić; Aleksandar Kamenov; Vladimir Stojiljković

Revascularization of the myocardium under conditions of extracorporeal circulation cause clinical problems related to the effects of the intervention itself on the immune system and inflammatory response, especially systemic inflammatory response (Engl. Systemic Inflammatory Response Syndrome, SIRS)


Infection-Related Morbidity and Mortality among Multiple Myeloma Patients in West Africa

Moussa Seck*; Moussa Traoré; Elimane Seydi Bousso; Alioune Badara Diallo; Sokhna Aissatou Touré; Mohamed Keita; Sérigne Mourtalla Guéye; Blaise Félix Faye; Abibatou Sall; Awa Oumar Touré; Saliou Diop

Multiple Myeloma (MM) is characterized by immunosuppression leading to increased susceptibility to infections. The aim of this study was to evaluate the morbidity and mortality of infections in patients followed for MM.


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