IMPACT FACTOR: 1.4
Short Name: Ann Oncol Case Rep
ISSN: 3142-886X
Publisher: MedDocs Publishers LLC
Representing approximately 5-10% of all Hodgkin lymphoma cases, Nodular Lymphocyte-Predominant Hodgkin Lymphoma (NLPHL) remains a rare entity with an incidence of 0.1 to 0.2 per 100,000 person-years. Although management has historically mirrored that of Classical Hodgkin Lymphoma (cHL), its distinct pathological and clinical profile has sparked an ongoing ...
The patient is an 87-year-old male with grade 3 pT2 cN0 cM0 urothelial carcinoma diagnosed in 2023, for whom radical surgery was not offered due to age. BCG instillations were planned. A few months later, the patient presented with a rapidly growing mass in the penis. He was then referred to our centre.
BRCA1 and BRCA2 mutations are strongly associated with homologous recombination deficiency in ovarian cancer and predict response to poly (ADP-ribose) Polymerase (PARP) inhibitors [1,2]. However, tumors lacking detectable BRCA mutations may still demonstrate a “BRCAness” phenotype through alternative molecular mechanisms such as BRCA1 promoter methylation [3,4].
Basal Cell Carcinoma, primarily occurring due to sunlight exposure, radiation, arsenic, immunosuppression or inherited conditions like Xeroderma pigmentosum, mostly present in sun-exposed areas of the head and neck but can also present elsewhere.
Targeted Osmotic Lysis (TOL) has been recently proposed as a novel, safe, and effective method for treating advanced carcinomas. The technique takes advantage of the finding that carcinomas greatly over-express Voltage-Gated Sodium Channels (VGSCs)
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