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Primary Signet-Ring Cell Adenocarcinoma of the Bladder Presenting with Severe Obstructive Uropathy and Mimicking Colorectal Carcinoma: A Rare Case Report

Asad Mehmood#*; Hassan Syed#; Haoliang Xu

    Adenocarcinoma in the bladder is extremely rare that is commonly divided as primary or secondary malignancy. Primary adenocarcinoma of the bladder, originated from bladder glandular epithelium, only accounts for a very small minority ...


Very Late Relapse of Nodular Lymphocytic-Predominant Hodgkin Lymphoma in a Young Adult

Álvaro Pimenta Dutra*; Gisela Cristina Ferlin de Souza; Juliana Lanza Neves

    Representing approximately 5-10% of all Hodgkin lymphoma cases, Nodular Lymphocyte-Predominant Hodgkin Lymphoma (NLPHL) remains a rare entity with an incidence of 0.1 to 0.2 per 100,000 person-years. Although management has historically mirrored that of Classical Hodgkin Lymphoma (cHL), its distinct pathological and clinical profile has sparked ...


Metastatic Urothelial Carcinoma Showing Exceptional Response with Trastuzumab Deruxtecan - A Case Report

Basile Saffiedine; Artemisia Kakourou; Antonia Stamatiou; Dominik Berthold*; Fitim Zulbeari

    The patient is an 87-year-old male with grade 3 pT2 cN0 cM0 urothelial carcinoma diagnosed in 2023, for whom radical surgery was not offered due to age. BCG instillations were planned. A few months later, the patient presented with a rapidly growing mass in the penis. He was then referred to our centre.


BRCA1 Promoter Methylation Leading to “BRCAness” and Response to Olaparib in BRCA1/2 Mutation-Negative High-Grade Serous Ovarian Carcinoma: A Case Report

Amit Bhargava*; Shruti Kulkarni; Mohit Kapoor

    BRCA1 and BRCA2 mutations are strongly associated with homologous recombination deficiency in ovarian cancer and predict response to poly (ADP-ribose) Polymerase (PARP) inhibitors [1,2]. However, tumors lacking detectable BRCA mutations may still demonstrate a “BRCAness” phenotype through alternative molecular mechanisms such as BRCA1 promoter methylation [3,4].


Basal Cell Carcinoma of Vulva with Situs Inversus Totalis: A Rarest of the Rare Phenomenon

Soham Gangopadhyay; Suranjan Maitra*; Sharad Sah; Priyanka L Mudunuri; Keya Basu

    Basal Cell Carcinoma, primarily occurring due to sunlight exposure, radiation, arsenic, immunosuppression or inherited conditions like Xeroderma pigmentosum, mostly present in sun-exposed areas of the head and neck but can also present elsewhere.


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