Press

Molecular Docking Study of different Natural Bio-Active Compounds of 'Swastha Kada Kashayam' on SARS-CoV-2 (nCoV) Proteins

Kalpana S*; Suganthan R; Prabu P

    Background: Since the COVID-19 a pandemic disease, so far there are no drugs or other treatment practices currently approved by the U.S. Food and Drug Administration (FDA) to treat COVID-19 patients. Current scenario is only clinical management includes infection prevention and control measures and supportive care, including oxygen supplementation and mechanical ventilatory support when indicated...


Animal Models of PCOS: A Comprehensive Review on Current Advancement, Diet-Microbiota Interactions and Future Trend on Developing PCOS Induced Rodent Models

Pritha Biswas; Pratip Chakraborty; Anindita Bhattacharya; Anamika Das; Mohan Das; Rintu Banerjee; Koel Chaudhury*

    Polycystic Ovary Syndrome (PCOS) accounts for a major form of dysovulatory infertility, often observed in ~15% women belonging to reproductive age. Being the etiology undecipherable and the management requiring a diversified approach, the call for a suitable animal model is warranted that will be able to mimic both reproductive as well as metabolic facets of the syndrome...


Breeding Approaches for Disease Resistance in Crop Plants: A Review

Shivam Maurya*; Mahabeer Singh; Sunil Kumar; Lalita Lakhran; Naresh Kumar; Satyadev Prajapati

    Present day agriculture has disturbed the age-vintage stability of host-pathogen system resulting diseases arise at regular interval leading to significant loss to the agricultural production, that is predicted to be 10-25% or much less in the course of everyday years however might also additionally enlarge as much as 100 % in the course of epidemic. Broadly, there are breeding tactics followed for disease resistance, which incorporates molecular and molecular one...


Novel Ink - Stained Reflectance Confocal Microscopy Guided Pigmented Skin Lesion Biopsy Technique: Reducing Pathology Sample Bias Through Improved Precision

Joanna Ludzik*; Claudia Lee; Alexander Witkowski; Jonathon Hetts; Sancy Leachman

    With skin cancer incidence rate steadily increasing each year, melanoma continues to pose a significant public health problem globally. It is well-known that early detection and prevention of melanoma remains the most important intervention for reducing morbidity and mortality, therefore it is imperative to promote innovation that will advance our ability to diagnose melanoma early...


Optical Coherence Tomography in Vivo inLaryngology Clinics, an Overview

Mette Pedersen*; Christian Larsen

    The aim of this review is to show the distance between the technical side of OCT and the understanding and needs of the laryngologists. In updated scientific research on OCT in laryngology, especially of the vocal folds, there are some obstacles of the techniques before the clinicians can use optical coherence tomography routinely.


Two-peak Elution Profile of a Bispecific VHH-IgG Fusion Protein in Ion Exchange Purification Process caused by Atypical N-Glycosylation

Jing Jiao; Liming Huang; Xiaohui Xu; Yuying Liu; Mingyan Hu; Weifeng Chen; Lei Li; Hui Xu; Xugang He; Nannan Li; Aihua Chen; Chenxi Shen; Lei Wang; Xun Liu; Lianshan Zhang; Chenxiang Tang*

    In-depth analysis and thorough understanding of N-glycosylation is critical for therapeutic proteins. For IgG or IgG-like molecules, the conserved N-glycosylation at Asn-297 has critical safety and efficacy implications and therefore is under close scrutiny. Any additional N-glycosylation that increases complexity and heterogeneity of the molecule, should be avoided at the early stage of drug discovery. However, unexpected glycosylation at atypical sites brings unforeseen challenges for antibody drug development process...


Extraction of essential oil from lemon and orange peel by Clevenger apparatus: Comparative GC_MS analysis of chemical composition, from Debre Berehan Market town Amahara Region Ethiopia

Zelalem Zayse Zeleke

    The peel of orange and lemon fruits is considered as a waste. It is used as a source of essential oils that can be applicable for food flavoring agent, pharmaceuticals, cosmetics, and soap and detergent factories. In this work, essential oils were extracted from lemon (1.56%) and orange (3.55%) peels by hydro distillation. The physiochemical properties of oils were recorded...


ApoB48 of Chylomicrons (CM) after Fat Load are Incorporated into the Liver and Reconstituted to VLDL ApoB48 in Humans

Yoshiharu Tokita*; Katsuyuki Nakajima*; Akira Tanaka

    The majority of Remnant Lipoproteins (RLP) in the postprandial plasma have been believed to be chylomicron (CM) remnants (exogenous remnants; RLP-apoB48) derived from the intestine, not VLDL remnants (endogenous remnants; RLP-apoB100) derived from the liver ..


Network Analyses of the Inventory of Interpersonal Problems-32 and the Associations of its Dimensions with Oppositional Defiant Disorder Dimensions in Emerging Adults

Rapson Gomez; Taylor Brown*

    Interpersonal relationship problems are key to Opposi tional Defiant Disorder (ODD). The study aimed to examine the types of interpersonal relationship problems, as pre sented in the Interpersonal Circumplex Model (IPC), with the ODD dimensions (oppositional, negative affect, and an tagonistic behavior) proposed by Burke et al. (2010).


Coronavirus: The Picture it Showed, the Message We Chose to Ignore!

Sudhakar Krittika; Pankaj Yadav*

    Nature needs to shake off the dust built due to its exploitation by humankind. One such heavy blow was probably the current COVID-19 pandemic. The COVID-19 pandemic has enabled habitat restoration of various wildlife and natural resources, along side the economic challenges it has imposed with increased poaching in certain countries ..


Recombinant DNA Technology Approaches to Words the Vaccination or Treatment Hepatitis B

Hamadullah Soomro

    Recombinant DNA technology is a crucial method that involves separating and inserting a gene of interest into a specific vector. One important application of this technology is in combating Hepatitis B, a widespread infectious disease in humans, by developing effective vaccines and treatments. ..


Development of DNA Aptamers that Detect Clonorchis Sinensis Adult Fluke and Egg Proteins by Enzyme-Linked Microplate Assay

John G Bruno*; Jeffrey C Sivils

    Development of DNA aptamers through ten rounds of selection and PCR amplification (SELEX) against recombinant adult Cs44 and Egg proteins of Clonorchis sinensis liver flukes is described along with the top three aptamer DNA sequences for each target derived from next generation sequencing. ..


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