Inflammatory Bowel Disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract (GIT) characterized by typical symptoms such as diarrhea, abdominal pain,cramping, rectal bleeding, loss of appetite, weight loss and fatigue.The exact cause of IBD is not clearly understood, but it is known to involve an interaction between genes, environmental factors such an imbalance of the intestinal microbiota, changing food habits, ultra hygiene and inappropriate immune system. Several mediators such as tumor necrosis factor- alpha (TNF-α), interleukin (IL)-1, matrix metalloproteinases (MMPs) and histamine play a significant role in the intensification and localization of inflammation associated with IBD.
Objective: The aim of present work was design, synthesis, characterization and pharmacological evaluation of colon-targeted macromolecular prodrug of mycophenolic acid for the effective management of IBD.
Ulcerative Colitis (UC) is an inflammatory disease resulting from an interaction between genetic and environmental factors and observed predominantly in developed countries. However incidence in developing countries is also on the rise, possibly as a result of more westernisation. UC is characterized by mucosal infl ammation of the rectum and to a variable extent the colon in a continuous fashion. Patients generally present with manifestations of the disease including abdominal pain, diarrhoea, rectal bleeding, and weight loss in the second or third decade of life.
Antibiotic Resistant Bacteria (ARB) occurrence and spread is causing problems related to public health all over the world and therefore is a reason of concern for the public [1]. Bacteria inherit resistance or develop resistance to some antibiotics through spontaneous mutation or incorporation of resistant genes [2]. Which are normally associated with mobile elements such as integrons, transposons and plasmids.
The relapsing and remitting character of CD results in accumulating damage to the bowel wall. Stricture is the most common complication of CD. Treatment of stricturing CD depends on the inflammatory or fibrotic character of the stricture. However, therapeutic management of stricturing CD remains a complex situation as it has been shown that inflammatory and fibrosis are two overlapping entities.
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