Inflammatory Bowel Disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract (GIT) characterized by typical symptoms such as diarrhea, abdominal pain,cramping, rectal bleeding, loss of appetite, weight loss and fatigue.The exact cause of IBD is not clearly understood, but it is known to involve an interaction between genes, environmental factors such an imbalance of the intestinal microbiota, changing food habits, ultra hygiene and inappropriate immune system. Several mediators such as tumor necrosis factor- alpha (TNF-α), interleukin (IL)-1, matrix metalloproteinases (MMPs) and histamine play a significant role in the intensification and localization of inflammation associated with IBD.
Objective: The aim of present work was design, synthesis, characterization and pharmacological evaluation of colon-targeted macromolecular prodrug of mycophenolic acid for the effective management of IBD.
Ulcerative Colitis (UC) is an inflammatory disease resulting from an interaction between genetic and environmental factors and observed predominantly in developed countries. However incidence in developing countries is also on the rise, possibly as a result of more westernisation. UC is characterized by mucosal infl ammation of the rectum and to a variable extent the colon in a continuous fashion. Patients generally present with manifestations of the disease including abdominal pain, diarrhoea, rectal bleeding, and weight loss in the second or third decade of life.
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