Curcumin with its anti-inflammatory properties is an ideal drug candidate to treat colonic diseases. Conventional dosage forms of curcumin are available but have limitations like low bioavailability of curcumin due to its degradation in stomach and short duration of action.
Inflammatory Bowel Disease (IBD) is a worldwide health problem and comprises Crohn’s Disease (CD) and Ulcerative Colitis (UC) as the two most prevalent pathologies. It has a direct connection with industrialized societies and all the changes imposed on individuals in this context, such as stress and dietary changes, in addition to the genetic predisposition and immunological factors.
Diet is known to play a profound role in the pathogenesis of inflammatory bowel disease (IBD) via mechanisms influencing the composition and function of the commensal microbiome. While difficult to isolate specific dietary components involved in the pathogenesis, etiology, or treatment of IBD, emerging data is consistent with the notion that a Western-style diet is associated with rising prevalence of IBD.
Normal sleep plays a pivotal role in maintaining the homeostatic balance between energy metabolism and the innate immune function within the gastrointestinal (GI) tract. While sleep is primarily centrally regulated in the hypothalamus by light-dark cycles, the majority of peripheral tissue exhibits circadian automaticity in function.
Lichen is a symbiotic form of a mycobiont and a photobiont or a cyanobiont. In the folk medicine of different cultures, they are used to treat multiple conditions such as wounds, skin disorders, respiratory and digestive problems, inflammation and its complications. Medicinal applications of lichens are documented in Ayurveda, Unani, and Doctrine of Signature with the contribution of knowledge from traditional medicinal practitioners.
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