Alzheimer's Disease (AD) is characterized as a chronic and progressive neurodegenerative disease with well-defined pathophysiological mechanisms, mostly affecting medial temporal lobe and associative neocortical structures [1]. Since its discovery some hundred years ago, AD continues to pose problems for affected families and society, especially in developed countries [2]. AD begins gradually; advances; and eventually leads to confusion, personality and behavior changes, and impaired judgment.
Cerebral Small Vessel Disease (CSVD) is one of the causes of AD development. This research focuses on the changes in dementia and cognitive functions in AD after restoration of cerebral distal arterial and capillary blood supply by transcatheter intracerebral laser revascularization. It also compares the results of this method with those of widespread conservative methods.
Alzheimer's Disease (AD) is a neurodegenerative (gradual loss of biological functions of nerves) disease characterized by precipitation of β-amyloid protein, so called amyloid plaque formation via metal-peptide interactions in the brain causing dementia (a syndrome due to brain disease, characterized by progressive deterioration in intellectual abilities).Two types of biochemical features of Alzheimer's Disease (AD) that contribute to neurodegeneration are intracellular oxidative stress and elevated level of trace metal ions, especially FeIII, CuII and ZnII.
Alzheimer's Disease (AD) is a progressive neurodegenerative condition with clinical features that include memory loss and cognitive deterioration. It belongs to the class of proteinopathies, thus being characterized by the aggregation of misfolded proteins. Intracellular Neurofibrillary Tangles (NFT), consisting of a highly phosphorylated form of the microtubule-bound tau protein, and extracellular amyloid plaques mainly composed of β-amyloid peptide appear to endorse the histopathology of AD. The process of association/dissociation of tau protein with Microtubules (MT) causes its involvement in MT dynamics and in neuronal axonal transport.
As the world population has aged, dementia has become a common diagnosis in aging populations and the numbers will increase in the forthcoming years. Globally, an estimated 47 million people are affected by dementia [1]. Alzheimer's Disease (AD) is the most common cause of dementia and one of the leading causes of morbidity and mortality in older adults.
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