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Chitosan-Based Delivery of an Isolated Plant- Derived Bioactive Compound Attenuates Proliferative Signaling Via the RAS–PI3K–AKT–mTOR Axis in Colorectal Cancer

Cletus Anes Ukwubile*; Babagana Modu; Hassan Braimah Yesufu; Sumaila Mejida; Emmanuel Oise Ikpefan

   Despite advancements in screening, diagnosis, and treatment approaches, Colorectal Cancer (CRC) is one of the most common cancers diagnosed globally and continues to be a major cause of cancer-related mortality, contributing significantly to the global disease burden [1-3]. Due to aggressive ...


Aseptic Spray Drying for Poorly Soluble Molecules

Shaukat Ali, PhD*; Jim Huang, PhD

   Spray drying technology has been used extensively for converting highly crystalline and high melting molecules to Amorphous Solid Dispersions (ASD) to overcome the solubility and bioavailability challenges [1].


Cytotoxicity of Zinc Oxide Nanoparticles: Recent Evidences and Biological Implications

Muhammad Tahir Saleh; Amjad Hussain*; Muhammad Sajid Hamid Akash; Faisal Attique; Khayala Mammadova; Yawar Abbas; Faryal Gohar; Muhammad Adnan Ayub

   Zinc oxide nanoparticles (ZnO-NPs) are being widely studied for biological applications due to their adjustable physicochemical characteristics and possible antibacterial and anticancer effects. However, variable toxicity results and unsolved biosafety issues preclude their clinical use.


PROTACS – A New Generation of Poorly Soluble and Permeable Molecules for Targeting Proteins

Shaukat Ali, PhD*; Jim Huang, PhD

   Proteolysis Targeting Chimeras (PROTACs) discovered over 20 years ago, have been classified as molecules beyond rule of five (bRoF), meaning they do not follow the classic Lipinski’s rule of five for solubility and bioavailability [1].


From Lab to Use: A Comprehensive Review of Chitosan Hydrogel Fabrication and Applications

Sravan Kumar Abburi; DhruvaKumar Chatrajupalli; Lahari Vuddanti; Seetharam Gude*

   Chitosan, a natural biopolymer obtained through the deacetylation of chitin, has gained significant attention due to its biodegradability, safety, and multifunctional biological properties.


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