Press

PROTACS – A New Generation of Poorly Soluble and Permeable Molecules for Targeting Proteins

Shaukat Ali, PhD*; Jim Huang, PhD

   Proteolysis Targeting Chimeras (PROTACs) discovered over 20 years ago, have been classified as molecules beyond rule of five (bRoF), meaning they do not follow the classic Lipinski’s rule of five for solubility and bioavailability [1].


From Lab to Use: A Comprehensive Review of Chitosan Hydrogel Fabrication and Applications

Sravan Kumar Abburi; DhruvaKumar Chatrajupalli; Lahari Vuddanti; Seetharam Gude*

   Chitosan, a natural biopolymer obtained through the deacetylation of chitin, has gained significant attention due to its biodegradability, safety, and multifunctional biological properties.


Lymphatic versus Portal Drug Delivery: An Understanding of Drug Oral Absorption and Food Effect

Shaukat Ali, PhD*; Jim Huang PhD

   As more new chemical entities are discovered with poor solubility and bioavailability, the applications of novel excipients and delivery technologies and their mechanisms by which the drug molecules are absorbed into systemic circulation, have been subject of continued interest [1].


Green Synthesis, Photo-Physical Characterization, and Evaluation of in-vitro Antioxidant, Anti-Inflammatory, and Antidiabetic Properties of Selenium Nanoparticles Derived from Nigella Sativa seeds

Kehinde Sowunmi; Oladosu Micheal Abimbola; Moses Adondua Abah*; Luqman Olaitan Sulaiman; Odimgbe Ezekiel Izudike; Ugwah Jiata Ekele; Dele-Osibanjo Taiwo A; Olowookere Adepeju Kafayat; Adewale Femi Emmanuel; Julius Sarah Oluwaseun; Nnametu Peter Onyedikachukwu; Agbanigo Bolade Sunday; Tobi David Farinde; Olutayo Nathaniel Farinde; Kelechi Asogwa; Taiwo Awojulu; Sunday Ameh

   Green synthesis of Selenium Nanoparticles (Se-NPs) harnesses plant resources to enhance therapeutic efficacy sustainably. Selenium Nanoparticles (Se-NPs) are known for their antioxidant, anti-inflammatory, and antidiabetic properties, making them promising candidates for addressing oxidative stress-related disorders


Advancement in Wound Healing by the Application of Folate Functionalized Metallic Colloidal Antibiotherapy

Roxane Abdel-Gawad*; Rihab Osman; Gehanne AS Awad; Nahed Mortada

   Folic Acid (FA) is introducing itself as a useful addition to wound management protocol. Herein, we report a novel eco-friendly method to prepare silver nanoparticles (AgNPs) using the anabolic FA as a reducing agent. The synthesis of FA-stabilized AgNPs (FA-AgNPs) was confirmed by spectrophotometric analysis, revealing the presence of the characteristic absorption peak corresponding to the Surface Plasmon Resonance of colloidal FA-AgNPs.


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